Freeze-dried hepatitis A attenuated live vaccine and its...

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Virus or component thereof

Reexamination Certificate

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C424S230100, C435S173300, C435S235100

Reexamination Certificate

active

06884422

ABSTRACT:
The present invention relates to hepatitis A vaccine, especially to a lyophilized attenuated hepatitis A vaccine which can be stored at ambient temperature for extended periods of time, and to a method for producing the same. The present invention further relates to a stabilizer for lyophilized live vaccine and its use in improving thermostability of lyophilized live vaccine during lyophilization processing and storage period after lyophilization.

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Hollinger et al. Hepatitis A Virus. In B.N. Fields et al. (ed.), Fields Virology, 3rd ed. Philadelphia: Lippencott-Raven Publishers; 1996: 739 and 766-769.*
Chiba-ken et al. (JP 1279843 abstract).

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