Fluoropyrrolidines having dipeptidyl peptidase enzyme...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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Details

C548S530000, C548S537000, C544S212000, C544S238000, C544S329000, C544S317000, C544S332000, C544S336000, C544S356000, C546S125000, C546S193000, C514S247000, C514S277000, C514S359000, C514S374000, C514S365000, C514S385000

Reexamination Certificate

active

08063045

ABSTRACT:
The present invention relates to new, potent DPP-IV enzyme inhibitors of the general formula (I), which contain fluorine atoms.

REFERENCES:
patent: 2004/0242636 (2004-12-01), Haffner et al.
patent: 2005/0176771 (2005-08-01), Hayakawa et al.
patent: PCT/JP03/09179 (2005-08-01), None
Morissette et al. Advanced Drug Delivery Reviews 2004, 56, 275-300.
Vippagunta et al., abstract, Vippagunta, Sudha R. “Crystalline Solids.” Advanced Drug Delivery Reviews 48(2001): 3-26.
Golub et al. Science (1999), vol. 286 531-537.
Lala et al. Cancer and Metastasis Reviews (1998), 17(1), 91-106.
Tautomer, Wikipedia (the free encyclopedia). Dec. 9, 2008, pp. 1-2.
Isomer—Wikipedia (the free encyclopedia), Dec. 9, 2008. pp. 1-4.
Patani, et al., Bioisoterism: A Rational Approach in Drug Design, Chem. Rev. (1996), vol. 96, pp. 3147-3176.
Morissette, et. al., High-throughput crystallization: polymorphs, salts, co-crystals and solvates of pharmaceutical solids, Advanced Drug Delivery Reviews (2004), vol. 56, pp. 275-300.
Vippagunta, S. R., et. al., Crystalline Solids, Advanced Drug Delivery Reviews (2001), vol. 48, pp. 3-26.

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