Fluorine-containing vitamin D.sub.2 derivatives

Details Fluorine-containing vitamin D.sub.2 derivatives Fluorine-containing vitamin D.sub.2 derivatives

1988-02-03

1991-09-10

Waddell, Frederick E.

Organic compounds -- part of the class 532-570 series

Organic compounds

9,10-seco-cyclopentanohydrophenanthrene ring system or...

C07J 900

Patent

active

050475649

ABSTRACT:
A fluorine-containing vitamin D.sub.2 derivative represented by the following formula ##STR1## wherein R.sup.1 represents a methyl or trifluoromethyl group, and R.sup.2 represents a trifluoromethyl group when R.sup.1 is a methyl group, and a hydrogen atom or a methyl group when R.sup.1 is a trifluoromethyl group. This compound is useful for the prevention or treatment of calcium pathobolism or osteoporosis.

REFERENCES:
patent: 4248791 (1981-02-01), DeLuca et al.
patent: 4284577 (1981-08-01), Yamada et al.
patent: 4521410 (1985-06-01), Holick et al.
patent: 4613594 (1986-09-01), Baggiolini et al.
Goodman et al., The Pharmacological Basis of Therapeutics, 1980, pp. 1544-1545.
"Induction of Monocytic Differentiation of HL-60 Cells by 1,25-Dihydroxyvitamin D Analogs", The Journal of Biological Chemistry, vol. 262, No. 25, 10-15-1987.

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