Chemistry: molecular biology and microbiology – Vector – per se
Reexamination Certificate
2011-05-10
2011-05-10
Joike, Michele K (Department: 1636)
Chemistry: molecular biology and microbiology
Vector, per se
C424S093100
Reexamination Certificate
active
07939318
ABSTRACT:
Herein-described are various methods for making a vaccine that are made of re-assembled virus like particles (VLP). First, the VLPs are disassembled into encapsidation intermediate populations. Each encapsidation intermediate population undergoes, for instance, chemical conjugation of unique peptide or nucleic moieties to form separate populations. Thereafter, a predetermined amount of each of the several (one or more) different encapsidation intermediates from the different populations is mixed and joined, forming intact VLPs, surrounding a nucleic acid core, that are composed of different encapsidation intermediate such that the reassembled VLP displays more than one peptide or nucleic acid. The nucleic acid can function either as a scaffold alone or can be engineered for the expression of an immunomodulatory protein in a eukaryotic cell.
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Lindbo John A.
McCormick Alison A.
Nguyen Long V.
Palmer Kenneth E.
Pogue Gregory P.
Joike Michele K
Kentucky Bioprocessing, LLC
Wyatt Tarrant & Combs LLP
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