Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1992-12-21
1996-07-16
Sidberry, Hazel F.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
4241841, 4241851, 530300, 530326, A61K 3902, A61K 3900, A61K 3702, C07K 1400
Patent
active
055364977
ABSTRACT:
Polypeptides related to fimbriae of Porphyromonas gingivalis are described and claimed which exhibit inhibition of bacterial adhesion to saliva-coated surfaces. The polypeptides are selected from the group consisting of fimbriae, fimbrillin, and fimbrial-related. peptides derived therefrom. The polypeptides are used as active ingredients in various oral formulations designed to prevent adhesion of P. gingivalis to host mucosal surfaces and thus interfering with the development of periodontitis. The polypeptides are also used in subunit vaccine formulations for use against pathogenic, fimbriated P. gingivalis in the prophylactic treatment of periodontitis. Use of the polypeptides for inducing protective immunity in serum and gingival crevicular fluid may prevent primary infection with P. gingivalis as well as the spread of the organism between intraoral reservoirs.
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Bedi Gurrinder S.
Evans Richard T.
Genco Robert J.
Sojar Hakimuddin T.
Sidberry Hazel F.
The Research Foundation of State University of New York
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