Fatty acid leukotriene synthesis inhibitors

Details Fatty acid leukotriene synthesis inhibitors Fatty acid leukotriene synthesis inhibitors

1986-08-29

1990-03-13

Evans, J. E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Radical -xh acid, or anhydride, acid halide or salt thereof...

260413, 514558, 514560, 562621, A61K 7119, A61K 13165, A61K 31215, C07C 5940

Patent

active

049083848

ABSTRACT:
Fatty acid compounds of the formula (I): ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, A, Y and k are as defined herein are novel and useful in the treatment of allergic and inflammatory disorders.

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patent: 4497827 (1985-02-01), Nelson
patent: 4564476 (1986-01-01), Ho
The Merck Index, 10th ed., (1983), p. 265, 1186 and 1187.
Tetrahedron Letters, vol. 24, No. 46, pp. 5139-5140, 1983, "Synthesis and 5-Lipoxygenase . . . ", Ackroyd et al.
"Trace Constituents in Milk Fat: . . . ", Weihrauch et al., Lipids 9(11):883-890 (1974).
"Synthesis of 4-4 Monohydroxyhexadecanoic Acids", Aliphatics, vol. 99, 1983, 99:21917p, pp. 569-570, Ozeris.
Chemical Abstracts, "Synthesis of Aryl and Arylalkyl Keto Acids by Oxidation with Chromium Trioxide", vol. 81, 1974, 151744u, Oyman.
"Metabolism of Hydroxy Fatty Acdis", The J. of Biochem., vol. 54, No. 6, 1963, Seiichi Okui et al., pp. 536-540.
"Metabolism of Hydroxy Fatty Acids", The J. of Biochem., vol. 58, No. 2, 1965, Michinao Mizugaki et al., pp. 174-178.

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