Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2007-03-27
2007-03-27
Rao, Deepak (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S266230, C514S267000, C544S252000, C544S284000
Reexamination Certificate
active
10381361
ABSTRACT:
This invention comprises the novel compounds of formula (I)wherein r, t, Y1—Y2, R1, R2, R3, R4, R5, R6and R7have defined meanings, having farnesyl transferase inhibiting activity; their preparation, compositions containing them and their use as a medicine.
REFERENCES:
patent: 6458800 (2002-10-01), Angibaud et al.
patent: 6914066 (2005-07-01), Angibaud et al.
patent: 0371564 (1990-06-01), None
patent: WO 97/16443 (1997-05-01), None
patent: WO 97/21701 (1997-06-01), None
patent: WO 98/40383 (1998-09-01), None
patent: WO 98/49157 (1998-11-01), None
patent: WO 98/55124 (1998-12-01), None
patent: WO 00/01386 (2000-01-01), None
patent: WO 00/01411 (2000-01-01), None
patent: WO 00/12498 (2000-03-01), None
patent: WO 00/12499 (2000-03-01), None
patent: WO 00/39082 (2000-07-01), None
patent: WO 00/47574 (2000-08-01), None
Simone, Oncology: Introduction, Cecil Textbook of Medicine, 20thEdition, vol. 1, pp. 1004-1010, 1996.
Nielsen et al., Combination Therapy with the Farnesyl Protein Transferase Inhibitor SCH66336 and SCH58500 (p53 Adenovirus) in Preclinical Cancer Models, Cancer Research, 59, pp. 5896-5901, Dec. 1999.
Tagawa, PubMed Abstract (Curr Pharm Des. 6(6):681-99) Apr. 2000.
Kohl et al., “Selective Inhibition of ras-Dependent Transformation by a Famesyltransferase Inhibitor,”Science, 1993, pp. 1934-1937, vol. 260, No. 5116.
Rak et al., “Mutant ras Oncogenes Upregulate VEGF/VPF Expression: Implications for Induction and Inhibition of Tumor Angiogenesis.”Cancer Research, 1995, pp. 4575-4580, vol. 55, No. 20.
Angibaud Patrick Rene
Mevellec Laurence Anne
Venet Marc Gaston
Janssen Pharmaceutica N.V.
Rao Deepak
LandOfFree
Farnesyl transferase inhibiting 6-heterocyclylmethyl... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Farnesyl transferase inhibiting 6-heterocyclylmethyl..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Farnesyl transferase inhibiting 6-heterocyclylmethyl... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3724189