Facile synthesis of arylmaleic acids and anhydrides

Details Facile synthesis of arylmaleic acids and anhydrides Facile synthesis of arylmaleic acids and anhydrides

1992-04-27

1993-04-27

Dentz, Bernard

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549253, 549254, 558373, 558406, 562465, 562484, C07C 5108, C07D30760

Patent

active

052063925

ABSTRACT:
A process for making acrylmaleic acid and arylmaleic anhydride derivative useful as intermediates for the preparation of arylmaleimides in the synthesis of compounds having activity in the central nervous system. The process involves reacting arylacetonitriles with glyoxylic acid to provide novel intermediate 3-aryl-3-cyanopropeneoates which may be converted to the arylmaleic acid and arylmaleic anhydride derivatives.

REFERENCES:
patent: 4132728 (1979-01-01), Verbrugge et al.

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