Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1997-01-24
1998-10-27
Ketter, James
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
4352521, 4353201, 435348, 435410, 536 237, C12P 2100, C12N 121, C12N 1563, C07H 2104
Patent
active
058276890
ABSTRACT:
FabD polypeptides and DNA (RNA) encoding such FabD and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such FabD for the treatment of infection, particularly bacterial infections. Antagonists against such FabD and their use as a therapeutic to treat infections, particularly bacterial infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence of FabD nucleic acid sequences and the polypeptides in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding Fab (Fatty acid biosynthesis) and for detecting the polypeptide in a host.
REFERENCES:
Orkin. Report and recommendations or the panel to assess teh NIH investment in research on gene therapy, Dec. 7, 1995.
Verwoert, et al., "Cloning, Nucleotide Sequence, and Expression of the Escherichia coli fabD Gene, Encoding Malonyl Coenzyme A-Acyl Carrier Protein Transacylase", Journal of Bacteriology, 174 No. 9, pp. 2851-2857 (May 1992).
Verwoert, et al., "Molecular characterization of an Escherichia coli mutant with a temperature-sensitive malonyl coenzyme A-acyl protein transacylase", FEBS Letters, 348, pp. 311-316 (1994).
Magnuson, et al., Cloning and nucleotide sequence of the fabD gene encoding malonyl coenzyme A-acyl carrier protein transacylase of Escherichia coli, FEBS Letters, 299 No. 3, pp. 262-266 (Mar. 1992).
Serre, et al., "The Escherichia coli Malonyl-CoA:Acyl Carrier Protein Transacylase at 1.5-.ANG. Resolution", Journal of Biological Chemistry, 270 No. 22, pp. 12961-12964 (1995).
Gentry Daniel Robert
Lonsdale John Timothy
Payne David John
Pearson Stewart Campbell
Gimmi Edward R.
Hecht Elizabeth J.
Ketter James
King William T.
Sandals William
LandOfFree
FabD polynucleotides does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with FabD polynucleotides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and FabD polynucleotides will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1613057