Expression of the virally coded protease P2A of HRV2

Details Expression of the virally coded protease P2A of HRV2 Expression of the virally coded protease P2A of HRV2

1988-12-23

1992-09-22

Nucker, Christine

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

15 to 23 amino acid residues in defined sequence

435 5, 530300, 530826, A61K 3702, C12Q 170

Patent

active

051497832

ABSTRACT:
This invention relates to a DNA molecule or a functional derivative thereof coding for a fusion protein, the fusion protein comprising an enzymatically active component and a non-enzymatically active polypeptide component which may be cleaved therefrom, an expression system which contains the DNA molecule, the use thereof as a test system for inhibitors of viral proteases, and an assay for identifying viral inhibitors.

REFERENCES:
patent: 4652552 (1987-03-01), Kettner et al.
Skern, T. et al., Nucleic Acids Res., 13:2111-2126 (1985).
Duechler, M. et al., Proc. Natl. Acad. Sci. USA., 84:2605-2609 (1987).
Stanway, G. et al., Nucleic Acids Res., 12:7859-7875 (1984).
Callahan, P. et al., Proc. Natl. Acad. Sci. USA., 82:732-736 (1985).
Butterworth, B., Virology, 56:439-453 (1973).
McLean and Rueckert, J. Virol., 11:341-344 (1973).
McLean, C. et al., J. Virol., 19:903-914 (1976).
Kowalski, H. et al., J. Gen. Virol., 68:3197-3200 (1987).
Korant, B. et al., J. Cellular Biochem., 32:91-95 (1986).
Geist, F. C. et al., Antimicrobial Agents Chemotherapy, 31:622-624 (1987).
Ivanoff, L. A. et al., Proc. Natl. Acad. Sci. USA., 83:5392-5396 (1986).
Toyoda, H. et al., Cell, 45:761-770 (1986).
Dewalt, P. et al., J. Virol., 61:2162-2170 (1987).
Werner, G. et al., J. Virol., 57:1084-1093 (1986).
Hanecak, R. et al., Cell, 37:1063-1073 (1984).
Korant, B. et al., Biomed. Biochim. Acta, 45:1529-1535 (1986).
Klump, W. et al., Proc. Natl. Acad. Sci. USA., 81:3351-3355 (1984).
Nicklin, M. et al., Proc. Natl. Acad. Sci. USA., 84:4002-4006 (1987).
Perrin, D. D. et al., Int'l Encyc. Pharm. of Therapeut., Ses. 111, pp. 288-302 (1984).

Affiliated with

Also associated with

Rating

Expression of the virally coded protease P2A of HRV2 does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Expression of the virally coded protease P2A of HRV2, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Expression of the virally coded protease P2A of HRV2 will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1069101