Expression of human milk proteins in transgenic plants

Food or edible material: processes – compositions – and products – Products per se – or processes of preparing or treating... – Plant material is basic ingredient other than extract,...

Reexamination Certificate

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C426S629000

Reexamination Certificate

active

06991824

ABSTRACT:
The invention is directed to food and food additive compositions comprising one or more human milk proteins produced in the seeds of a transgenic plant and methods of making the same. The invention is further directed to improved infant formula comprising such food supplement composition.

REFERENCES:
patent: 4977137 (1990-12-01), Nichols et al.
patent: 5543576 (1996-08-01), van Ooijen et al.
patent: 5850016 (1998-12-01), Jung et al.
patent: 5994628 (1999-11-01), Rodriguez
patent: 6020015 (2000-02-01), Gaull
patent: 6270827 (2001-08-01), Gaull et al.
patent: 6545198 (2003-04-01), Echelard et al.
patent: 6569831 (2003-05-01), Legrand et al.
patent: 6596767 (2003-07-01), Masor et al.
patent: 6635806 (2003-10-01), Kriz et al.
patent: 2002/0192296 (2002-12-01), Gauli et al.
patent: 2003/0229925 (2003-12-01), Legrand et al.
patent: WO 98/05788 (1998-02-01), None
patent: WO 98/10062 (1998-03-01), None
patent: WO 98/59062 (1998-12-01), None
patent: 00/04146 (2000-01-01), None
patent: WO 02/063975 (2002-08-01), None
Lonnerdal, B. “Expression of human milk proteins in plants”. J. American College of Nutrition. 21(3):218S-221S. 2002.
Arakawa et al. “Improvements in human health through production of human milk proteins in transgenic food plants”. Advance in Exper. Med. & Biol. vol. 464, p. 149-159. 1999.
Sovyanhadi et al. “Human beta-casein gene expression in transgenic tomato plants”. Transgenics 3(2-4):199-206. 2001.
Lohmann et al.,Cell105:793-803, 2001.
Russell DA and ME Fromm, (1997), “Tissue specific expression in transgenic maize of four endosperm promoters from maize and rice,”Transgenic Res6:157-168.
Genschick P, et al., (1994), “Structure and promoter activity of a stress and developmentally regulated polyubiquitin-encoding gene ofNicotiana tabacum,”Gene148:195-202.
McElroy DE, et al., (1990), “Isolation of an efficient actin promoter for use in rice transformation,”Plant Cell2:163-171.
Wang Y, et al., (1992), “Characterization of cis-acting elements regulating transcription from the promoter of a constitutively active rice actin gene,”Molec Cell Biol12(8):3399-3406.
Washida H, et al., (1999), “Identification of cis-regulatory elements required for endosperm expression of the rice storage protein glutelin gene GluB-1,”Plant Molec Biol40:1-12.
Cercós M, et al., (1999), “Hormonal regulation of a cysteine proteinase gene, EPB-1, in barley aleurone layers: cis and trans-acting elements involved in co-ordinated gene expression regulated by gibberellins and abscisic acid,”Plant Journal19(2):107-118.
Holdsworth MJ, et al., (1995), “The maize transcription factor Opaque-2 activates a wheat glutenin promoter in plant and yeast cells,”Plant Molec Biol29:711-720.
Schmidt RJ, et al., (1992), “Opaque-2 is a transcriptional activator that recognizes a specific target site in 22-kD zein genes,”Plant Cell4:689-700.
Wu Cy, et al., (1998), “The GCN4 motif in a rice glutelin gene is essential for endosperm-specific gene expression and is activated by Opaque-2 in transgenic rice plants,”Plant Journal14(6):673-683.
Mena Mi, et al., (1998), “An endosperm-specific DOF protein from barley, highly conserved in wheat, binds to and activates transcription from the prolamin-box of a native B-hordein promoter in barley endosperm,”Plant Journal16(1): 53-62.
Vicente-Carbajosa V, et al., (1998), “Barley BLZ1: a bZIP transcriptional activator that interacts with endosperm-specific gene promoters,”Plant Journal13(5):629-640.
Schwechheimer et al.,Funct Intergr Genomics1:35-43, 2000.
Izawa et al.,J. Mol. Biol. 230:1131-1144, 1993.
Hao et al.,The J. of Biological Chemistry273(41):26847-26861, 1998.
Busch et al.,Science285:585-587, 1999.
Albani, D. et al., “The Wheat Transcriptional Activator SPA: A Seed-Specific bZIP Protein That Recognizes the GCN4-like Motif in the Bifactorial Endosperm Box of Prolamin Genes,”Plant Cell, 9:171-184, 1997.
GenBank Accession No. AB021736 Oryza sativa gene for bZIP protein, complete cds, date NA.
GenBank Accession No. D11385 Oryza sativa mRNA for prolamin, complete cds, date NA.
GenBank Accession No. M29411 Z. mays DNA binding protein opaque-2 (O2) mRNA, complete cds, date NA.
GenBank Accession No. U82230 Zea mays endosperm-specific prolamin box ginding factor (PBF) mRNA, complete cds, date NA.
GenBank Accession No. X15544 Xea mays opaque-2 gene, date NA.
Muller, M. et al., Regulation of Storage Protein Synthesis in Cereal Seeds: Developmental and Nutritional Aspects,J. Plant Physiol., 145:606-608, 1995.
Nakase, M. et al., “Characterization of a novel rice bZIP protein which binds to the α-globulin promoter,”Plant Mol Biol, 33(3):513-522, 1997.
Vicente-Carbajosa, J. et al., “A maize zinc-finger protein binds the prolamin box in zein gene promoters and interacts with the basic leucine zipper transcriptional activator Opaque-2,”Proc. Natl. Acad. Sci., USA, 94:7685-7690, 1997.
Terashima, M. et al., “Production of functional human α1-antitrypsin by plant cell culture,”Appl. Microbiol Biotechnol. 52:516-523, 1999.
Arakawa, T. et al., “Improvements in Human Health through Production of Human Milk Proteins in Transgenic Food Plants,”Cehmicals via Higher Plant Bioengineering, pp. 149-159, 1999.
Bosch, D. et al., “A trout growth hormone is expressed, correctly folded and partially glycosylated in the leaves but not the seeds of transgenic plants,”Transgenic Research3:304-310, 1994.
Chong, D.K.X. et al., “Expression of the human milk protein β-casein in transgenic potato plants,”Transgenic Research6:289-296, 1997.
Lönnerdal, B., “Recombinant human milk proteins—an opportunity and a challenge,”Am. J.. Clin. Nutr. 63:4, 621S-626S, 1996.
Qiu, J. et al., “Human milk lactoferrin inactivates two putative colonization factors expressed byHaemophilus influenzae,” Proc. Natl. Acad. Sci. USA95:12641-12646, 1998.
Horvath, H. et al., “The production of recombinant proteins in transgenic barley grains,”PNAS97:4, 1914-1919, 2000.
Lönnerdal, B. and Iyer S., “Lactoferrin: Molecular Structure and Biological Function”,Annual Reviews Nutr. 15:93-110, 1995.
Salmon, V. et al., “Production of Human Lactoferrin in Transgenic Tobacco Plants”,Protein Expression and Purificaiton13:127-135, 1998.
Chong, D. K. X. et al., Expression of full-length bioactive antimicrobial human lactoferrin in potato plantsTransgenic Research9:71-78, 2000.

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