Chemistry: molecular biology and microbiology – Micro-organism – per se ; compositions thereof; proces of... – Bacteria or actinomycetales; media therefor
Patent
1994-04-19
1996-07-30
Wax, Robert A.
Chemistry: molecular biology and microbiology
Micro-organism, per se ; compositions thereof; proces of...
Bacteria or actinomycetales; media therefor
536 235, 4353201, C12N 120, C12N 1563, C07H 2104
Patent
active
055411096
ABSTRACT:
This invention provides a unique SH3 binding domain core motif of the sequence RPLPXXP and cDNA clones encoding proteins which interact with the SH3 domain of c-src, as well as the amino acid sequences which mediate this binding.
Another embodiment of this invention is a method of identifying SH3-binding proteins and elucidating the sequences which mediate binding. This method may be used as an assay to select compounds which bind to this site and which inhibit or enhance the binding of the SH3 domain.
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Cheadle Christopher
French Stephen M.
Ivashchenko Yuri D.
Jaye Michael C.
Ricca George A.
Goodman Rosanne
Lau Kawai
Parker III Raymond S.
Rhone-Poulenc Rorer Pharmaceuticals Inc.
Smith Julie K.
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