Exoenzyme toxin of Aeromonas salmonicida , and uses thereof

Details Exoenzyme toxin of Aeromonas salmonicida , and uses thereof Exoenzyme toxin of Aeromonas salmonicida , and uses thereof

2008-04-01

2008-04-01

Graser, Jennifer E. (Department: 1645)

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

C536S023700, C536S024100, C536S024200, C435S069300, C435S071100, C435S243000, C435S252100, C435S252300, C435S320100, C424S236100, C424S234100

Reexamination Certificate

active

10416981

ABSTRACT:
A protein toxin namedAeromonas salmonicidaexoenzyme T (AcxT), which belongs to the family of ADP-ribosylating toxins, is disclosed as is a Calcium (or other cation concentration) dependent promoter ofA. salmonicida. Also disclosed are diagnostic, preventive, and therapeutic techniques, including the preparation of bacterin vaccines based on AexT for inducing immunity againstA. salmonicidainfections.

REFERENCES:
patent: WO 92/21370 (1992-12-01), None
patent: WO 97/23503 (1997-07-01), None
Bowie et al., Science 247:1306-1310, p. 1306.
Mikayama et al. (Nov. 1993. Proc.Natl.Acad.Sci. USA, vol. 90 : 10056-10060).
Rudinger et al. (Jun. 1976. Peptide Hormones. Biol.Council. pp. 5-7).
Braun et al. (Submitted. Jul. 19, 2000. GenEmbl: Database. Accession No. AF288366).
Database Swall ′Online! EBI; Nov. 1, 1996 “ExoT ofP. aeruginosa,” Database Accession No. Q51445, XP-002216069.
Database EMBL ′Online! EBI; Aug. 2, 2001 “Aeromonas salmonicidaADP-ribosyltransferase gene (aexT), complete cds and unknown gene,” Database Accession No. AF288366, XP-002216070.
Database Swall ′Online! EBI; Nov. 1, 1996 “ExoS ofP. aeruginosa” Database Accession No. Q51448, XP-002216071.

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