Exo- and diastereo- selective syntheses of himbacine analogs

Details Exo- and diastereo- selective syntheses of himbacine analogs Exo- and diastereo- selective syntheses of himbacine analogs

2006-01-12

2009-10-20

Morris, Patricia L (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

active

07605275

ABSTRACT:
This application discloses a novel process for the preparation of himbacine analogs useful as thrombin receptor antagonists. The process is based in part on the use of a base-promoted dynamic epimerization of a chiral nitro center. The chemistry taught herein can be exemplified by the following:

REFERENCES:
patent: 6063847 (2000-05-01), Chackalamannil et al.
patent: 6326380 (2001-12-01), Chackalamannil et al.
patent: 6645987 (2003-11-01), Chackalamannil et al.
patent: 7235567 (2007-06-01), Wu
patent: 7304078 (2007-12-01), Chackalamannil et al.
patent: WO 03/089428 (2003-10-01), None
International Search Report, PCT/US2006/000954; mailed Aug. 7, 2006.6 pages.
Chackalamannil, S., et. al.;“Discovery of Potent Orally Active Thrombin Receptor (Protease Activated Receptor 1 ) Antagonists as Novel Antithrombotic Agents”, J.Med.Chem, Sep. 22, 2005 ; vol. 48, No. 19, pp. 5884-5887, web published Aug. 24, 2005.
Clasby, M. C., et. al.; “Discovery & Synthesis of a novel series of quinoline-based thrombin reecptor (PAR-1) Antagonists” Bioorganic and Medicinal Letters ; Mar. 15, 2006; vol. 16, No. 6; pp. 1544-1548; web published Dec. 27, 2005.
Hatayama, K., et. al.; “Production of optically active propargyl alcohol derivs.—e.g.alkoxy-hydroxy-butyne or deriv., by acylating in presence of enzyme”; Derwent; Abstract; 1996—040245; 2 pages.
Tao, Beata, et. al.; “Nonenzymatic Kinetic Resolution of Propargylic Alcohols by a Planar-Chiral DMAP Derivative: Crystallographic Characterization of the Acylated Catalyst”; J. Am. Chem. Soc.; 1999; 121; pp. 5091-5092; web published May 14, 1999.

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