Excitatory amino acid antagonists

Organic compounds -- part of the class 532-570 series – Organic compounds – Phosphorus acids or salts thereof

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C07F 938, A61K 3166

Patent

active

052568148

ABSTRACT:
An unexpectedly more potent isomer of 2-amino-4,5-(1,2-cyclohexyl)-7-phosphonoheptanoic acid, a known excitatory amino acid antagonist, pharmaceutical compositions including this isomer and methods of using this isomer to antagonize excitatory amino acid receptors.

REFERENCES:
patent: 4761405 (1988-08-01), Rzeszotarski et al.
Ferkany, J. W. et al., Pharmacological Profile of NPC 12626, A Novel, Competitive N-Methyl-D-Aspartate Receptor Antagonists J.P.E.T. 250:100-109 (1989).
Willets, J. and R. L. Balster, Pentobarbital-Like Discriminative Stimulas Effects of N-Methyl-D-Asparate Antagonists, J.P.E.T. 249:438-443 (1989).
Syldatk, C. et al., *Abstract & Review Only* Microbial, Enantioselective Hydrolysis of D,L-5-Monosubstituted Hydantoins for the Production of D-N-L-Amino Acids, Biotech Forum: 9-19 (1986).
Olivieri, R. et al., Mictobial Transformation of Racemic Hydantoins to D-Amino Acids, Biotechnololgy and Bioengineering 23: 2173-2183 (1981).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Excitatory amino acid antagonists does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Excitatory amino acid antagonists, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Excitatory amino acid antagonists will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-960582

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.