Excitatory amino acid antagonists

Details Excitatory amino acid antagonists Excitatory amino acid antagonists

1992-07-24

1993-10-26

Dees, Jose G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Phosphorus acids or salts thereof

C07F 938, A61K 3166

Patent

active

052568148

ABSTRACT:
An unexpectedly more potent isomer of 2-amino-4,5-(1,2-cyclohexyl)-7-phosphonoheptanoic acid, a known excitatory amino acid antagonist, pharmaceutical compositions including this isomer and methods of using this isomer to antagonize excitatory amino acid receptors.

REFERENCES:
patent: 4761405 (1988-08-01), Rzeszotarski et al.
Ferkany, J. W. et al., Pharmacological Profile of NPC 12626, A Novel, Competitive N-Methyl-D-Aspartate Receptor Antagonists J.P.E.T. 250:100-109 (1989).
Willets, J. and R. L. Balster, Pentobarbital-Like Discriminative Stimulas Effects of N-Methyl-D-Asparate Antagonists, J.P.E.T. 249:438-443 (1989).
Syldatk, C. et al., *Abstract & Review Only* Microbial, Enantioselective Hydrolysis of D,L-5-Monosubstituted Hydantoins for the Production of D-N-L-Amino Acids, Biotech Forum: 9-19 (1986).
Olivieri, R. et al., Mictobial Transformation of Racemic Hydantoins to D-Amino Acids, Biotechnololgy and Bioengineering 23: 2173-2183 (1981).

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