Ex vivo activation of immune cells

Chemistry: molecular biology and microbiology – Spore forming or isolating process

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4352402, 43524021, 935108, C12N 500, C12N 508

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active

057669201

ABSTRACT:
Disclosed is a process of activating patient-derived mononuclear cells by exposing the cells in vitro to substances wo generate immunoreactive cells. The ex vivo activated cells are then reinfused into the patient to enhance the immune system to treat various forms of cancer, infectious diseases, autoimmune diseases or immune deficiency diseases.

REFERENCES:
patent: 4172124 (1979-10-01), Koprowski et al.
patent: 4211766 (1980-07-01), Bjorklund
patent: 4361550 (1982-11-01), Kung et al.
patent: 4404280 (1983-09-01), Gillis
patent: 4444887 (1984-04-01), Hoffmann
patent: 4451570 (1984-05-01), Royston et al.
patent: 4474876 (1984-10-01), Osband et al.
patent: 4690915 (1987-09-01), Rosenberg
patent: 4704273 (1987-11-01), McMichael
patent: 4710380 (1987-12-01), Gottlieb
patent: 4716111 (1987-12-01), Osband et al.
patent: 4778750 (1988-10-01), Gottlieb
patent: 4849329 (1989-07-01), Leung et al.
patent: 4876193 (1989-10-01), Gottlieb
patent: 5026365 (1991-06-01), Rossini et al.
patent: 5192537 (1993-03-01), Osband
patent: 5316763 (1994-05-01), Ochoa et al.
Abb, J., et al., "Lymphocyte Activation by the Tumor-Promoting Agent 12-O-Tetradecanoylphorbol-13-Acetate (TPA)", J. Immunology, 122:1639-1642.
McCrady, C., et al., "Alteration of Human Lymphokine-activated Killer Cell Activity by Manipulation of Protein Kinase C and Cytosolic Ca.sup.2+1 ", 1988, Cancer Research, 48:635-640.
Chatenoud, L., et al., "Restriction of the Human in Vivo Immune Response Against the Mouse Monoclonal Antibody OKT3.sup.1 ", 1986, J. Immunology, 137:830-38.
Kradin, R., et al. "Tumour-Infiltrating Lymphocytes and Interleukin-2 in Treatment of Advanced Cancer", 1989, The Lancet, I:577-80.
Margolin, K., et al., "Interleukin-2 and Lymphokine-Activated Killer Cell Therapy of Solid Tumors: Analysis of Toxicity and Management Guidelines", 1989, J. Clin. Oncology, 7:486-98.
Rosenberg, S., et al., "A New Approach to the Adoptive Immunotherapy of Cancer with Tumor-Infiltrating Lymphocytes", 1986, Science, 233:1318-1321.
Rosenberg, S., et al., "Observations on the Systemic Administration of Autologous Lymphokine-Activated Killer Cells and Recombinant Interleukin-2 to Patients with Metastatic Cancer", 1985, N.E. J. Medicine, 313:1485-92.
Rosenberg, S., "Adoptive Immunotherapy of Cancer Using Lymphokine Activated Killer Cells and Recombinant Interleukin-2", Important Advances in Oncology; DeVita et al., (eds.); J.B. Lippincott Company, Philadelphia, 1986, Ch. 4, pp. 55-91.
Schoof, D., et al., "Adoptive Immunotherapy of Human Cancer Using Low-Dose Recombinant Interleukin 2 and Lymphokine-activated Killer Cells", 1988, Cancer Res., 48:5007-10.
Seder, R., et al., "Acqusition of Lymphockine-Producing Phenotype by CD4.sup.+ T Cells", 1994, Annual Rev. of Immunology, 12:635-73.
Siegel, J,. et al., "Interleukin-2 Toxicity", 1991, J. Clin. Oncology, 9:694-704.
Spiess, P., et al., "In Vivo Antitumor of Tumor-Infiltrating Lymphocytes Expanded in Recombinant Interleukin-2", 1987, J. Nat'l Cancer Institute, 79:1067-75.
Vigeral, P., et al., "Prophylactic Use of OKT3 Monoclonal Antibody in Cadaver Kidney Recipients", 1986, Transplantation, 41:730-33.
West, W., et al., "Constant-Infusion Recombinant Interleukin-2 in Adoptive Immunotherapy of Advanced Cancer", 1987, N.E. J. Medicine, 316:898-905.
Abb et al., "Lymphocyte Activation by the Tumor-Promoting Agent 12-0-Tetradecanoylphorbol-13-Acetate (TPA)", J. of Immunology 122:1639-1642, 1979.
Abulafia et al., "In Vitro Production of T Cells Immunoreactive Against Prostate Specific Antigen:A Novel Approach for an Antigen-Specific Adoptive . . . ", Am. Soc. for Biochemistry & Molecular Biology 1896, 1990.
Aliski et al., "The Regulation of Living Cell Therapies (Biocare)", Regulatory Affairs 3:639-650, 1991.
Carpinito et al., "Successful Adoptive Immunotherapy of Cancer Using In Vitro Immunized Autologous Lymphocytes and Cimetidine", Am. College of Surgeons 1986 Surgical Forum 27:418-421, 1986.
Cavagnaro et al., "Successful In Vitro Primary Immunization of Human Peripheral Blood Mononuclear Cells and its Role in the Development of Human-Derived Monoclonal Antibodies", Biotechniques 1:30-36, 1983.
Celis et al., "Peptide-Induced Proliferation and Lymphokine Production in Human T Cells in the Absence of Antigen-Presenting Cells:Role of T-Cell Activation State and . . . ", Human Immunology 34:173-180, 1992.
Darrow et al., "Modulation of In Vitro Autologous Melanoma-Specific Cytotoxic T-Cell Responses by Phorbol Dibutyrate and Ionomycin", Cellular Immunology 125:508-517, 1990.
Delfraissy et al., "Primary in Vitro Antibody Response from Human Peripheral Bloody Lymphocytes", J. of Immunology 118:630-635, 1977.
du Moulin et al., "Quality Assurance and Quality Control (QA/QC) in Biocare, Autolymphocyte Therapy as a Model", Clinical Immunology Society, 1989.
du Moulin et al., "Implementation of an Effective Program for Quality Assurance and Quality Control in Living Cell Therapy:A 2-Year Experience with . . . ", Transplantation Proceedings 24:2802-2808, 1992.
du Moulin et al., "Use of Limulus Amebocyte Lysate (LAL) Assay in Living Cell Therapies", Biopharm, 1992.
du Moulin et al., "Quality Assurance/Quality Control Compliance Program:A Cellular Therapy Developer's Perspective", Regulatory Affairs 5:461-472, 1993.
Fauci et al., "Activation of Human B Lymphocytes, I. Direct Plaque-Forming Cell Assay for the Measurement of Polyclonal Activation and Antigenic Stimulation of . . . ", J. of Experimental Medicine 144:674-684, 1976.
Feinfeld et al., "Interstitial Nephritis in a Patient Receiving Adoptive Immunotherapy with Recombinant Interleukin-2 and Lymphokine-Activated Killer Cells", Am. J. Nephrol 11:489-492, 1991.
Frenster et al., "In-Vitro Activation and Reinfusion of Autologous Human Lymphocytes", The Lancet 979-980, 1968.
Geha et al., "Interaction of Human Thymus-Derived And Non-Thymus-Derived Lymphocytes in Vitro", J. of Experimental Medicine 138:1230-1247, 1973.
Gifford et al., "Cimetidine-Induced Augmentation of Human Lymphocyte Blastogenesis by Mitogen, Bacterial Antigen and Alloantigen", Biological Abstracts 70:4655, 1980.
Graham et al., "The Use of Ex Vivo-Activated Memory T Cells (Autolymphocyte Therapy) in the Treatment of Metastatic Renal Cell Carcinoma:Final Results From a Randomized, . . . ", Seminars in Urology 11:27-34, 1993.
Hirai et al., "Temperature Influences on Different Human Alpha Interferon Activities", J. of Interferon Research 4:507-516, 1984.
Hoffman, "Antigen-Specific Induction and Regulation of Antibody Synthesis in Cultures of Human Peripheral Blood Mononuclear Cells", Proc. Natl. Acad. Sci. USA 77:1139-1143, 1980.
Kanazawa et al., "Serum from Patients with Autoimmune Diseases Induces in Vitro Production of Disease-Associated Antibodies by Peripheral Blood . . . ", J. of Clinical Endocrinology and Metabolism 63:683-688, 1986.
Kessler et al., "Regulation of Somatic-Cell Therapy and Gene Therapy by the Food and Drug Administration", The New England J. of Medicine 329:1169-1173, 1993.
Krane et al., "Treatment of Metastatic Renal Cell Carcinoma with Autolymphocyte Therapy, Low Toxicity Outpatient Approach to Adoptive Immunotherapy Without Use . . . ", Urology 35:417-422, 1990.
Lavin et al., "Autolymphocyte Therapy for Metastatic Renal Cell Carcinoma:Initial Clinical Results From 335 Patients Treated in a Multisite Clinical Practice", Transplantation Proceedings 24:3059-3064, 1992.
Lotze et al., "Lysis of Fresh and Cultured Autologous Tumor by Human Lymphocytes Cultured in T-Cell Growth Fact", Cancer Research 41:4420-4425, 1981.
Lotze et al., "In Vitro Growth of Cytotoxic Human Lymphocytes, II. Use of T Cell Growth Factor (TCGF) to Clone Human T Cells", The J. of Immunology 124:2972-2978, 1980.
Lotze et al., "The In Vitro Distribution of Autologous Human and Murine Lymphoid Cells Grown in T Cell Growth Factor (TCGF):Implications for the Adoptive . . . ", The J. of Immunology 125:1487-1493, 1980.
Mazumder et al., "Lysis of Fresh Human Solid Tumors by Autologous Lymphocytes Activated In Vitro with Lectins", Cancer Res. 42:913-918, 1982.
McCrady et al., "Alteration of Human Lymphokin

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