Erythromycin D and esters thereof by fermentation with Nocardia

Details Erythromycin D and esters thereof by fermentation with Nocardia Erythromycin D and esters thereof by fermentation with Nocardia

1984-04-16

1986-04-15

Shapiro, Lionel M.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound containing saccharide radical

435253, 435872, C12P 1962, C12N 120, C12R 1365

Patent

active

045827966

ABSTRACT:
Fermentation of a culture of Nocardia sp. ATCC 39043 produces an antibiotic complex comprising erythromycin D, 3",4"-di-O-acetylerythromycin D, 3"-O-acetyl-4"-O-propionylerythromycin D and 4"-O-acetylerythromycin D. The components are separated and are each useful in vitro and in vivo as antibacterial agents. If erythromycin D is the desired product, the esters can be hydrolyzed prior to the separation of the erythromycin D.

REFERENCES:
patent: 3884903 (1975-05-01), Jones et al.
patent: 4298600 (1981-11-01), Higashide et al.
patent: 4363803 (1982-12-01), Hauske
Majer et al., J. Am. Chem. Soc., 99: 1620-1622, (1977).
Jones et al., J. Med. Chem. 15, pp. 631-634, (1972).
Martin et al., J. Med. Chem., 15, pp. 635-638, (1972).
Bartner et al., J. Chem. Soc., Perkin I, pp. 1600-1624, (1979).

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