Era of Streptococcus pneumoniae

Details Era of Streptococcus pneumoniae Era of Streptococcus pneumoniae

1997-09-22

2000-12-26

Priebe, Scott D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

435 691, 4353201, 4352523, 43525411, 435325, 536 231, 536 232, 536 237, A61K 4800, C07H 2100, C12N 1531, C12N 1563

Patent

active

061659894

ABSTRACT:
The invention provides era polypeptides and DNA (RNA) encoding era polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing era polypeptides to screen for antibacterial compounds.

REFERENCES:
Ben-Yedidia et al., "Design of peptide and polypeptide vaccines", Curr. Opin. Biotechnol. 8: 442-448, Aug. 1997.
Ngo et al., "Computational complexity, protein structure prediction, and the Levinthal paradox", in `The Protein Folding Problem and Tertiary Structure Prediction`, Merz et al. (eds.), Birkhauser Boston: Boston, MA, pp. 433 & 492-495, 1994.
GenBank Acc. No. 585107, Yamashita et al., "GTP-binding protein Era homolog", U.S. National Library of Medicine, accessed by PTO on Aug. 19, 1998, Oct. 1994.
GenBank Acc. No. LO3428, Yamashita et al., "Streptococcus mutans G protein (spg) gene sequence", U.S. National Library of Medicine, accessed by PTO on Aug. 19, 1998, Oct. 1993.
Paul E. March, "Membrane-associated GTPases in bacteria", Molecular Biology, vol. 6, No. 10, pp. 1253-1257, 1992.
Gollop, et al., "Localization of the membrane binding sites of Era in Escherichia coli" Res. Microbiology, vol. 142, pp. 301-307, 1991.
Pillutla, et al., "Cross-Species Complementation of the Indispensable Escherichia coli era Gene Highlights Amino Acid Regions Essential for Activity", Journal of Bacteriology, vol. 177, No. 8, pp. 2194-2196, Apr., 1995.
Lerner, et al., "Pleiotropic changes resulting from depletion of Era, an essential GTP-binding protein in Escherichia coli" Molecular Microbiology, vol. 5, No. 4, pp. 951-957, 1991.
Chen, et al., "Expression and Characterization of RNase III and Era Proteins", Products of the rnc Operon of Escherichia Coli, The Journal of Biological Chemistry, vol. 265, No. 5, pp. 2888-2895, Feb., 1990.
Ahnn, et al., "A GTP-binding protein of Escherichia coli has homology to yeast RAS proteins", Proc. Natl. Sci., USA, vol. 83, pp. 8849-8853, Dec. 1986.
Lerner, et al., "Cold-sensitive growth and decreased GTP-hydrolytic activity from substitution of Pro 17 for Val in Era, an essential Escherichia coli GTPase", FEMS Microbiology Letter 95, pp. 137-142, 1992.
Sood, et al., "Characterization of the Autophosphorylation of Era, an essential Escherichia coli GTPase", Molecular Biology, vol. 12, No. 2, pp. 201-208, 1994.
Inada, et al., "Temperature-Sensitive Lethal Mutant of Era, a G Protein in Escherichia Coli", Journal of Bacteriology, vol. 171, No. 9, pp. 5017-5024, Sep. 1989.
Gollop, et al., "A GTP-Binding Protein (Era) Has an Essential Role in Growth Rate and Cell Cycle Control in Eschericia Coli", Journal of Bacteriology, vol. 173, No. 7, pp. 2265-2270, Apr. 1991.
Yamashita, et al., "Molecular Characterization of a Streptococcus mutans Mutant Altered in Environmental Stress Responses", Journal of Bacteriology, vol. 175, No. 19, pp. 6220-6228, Oct. 1993.
Pillutla, et al., "Deletion of the putative effector region of Era, an essential GTP-binding protein in Escherichia coli, causes a dominant-negative phenotype", FEMS Microbiology Letters, vol. 143, pp. 47-55, 1996.

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