Enzymatic analysis using substrates that yield fluorescent preci

Details Enzymatic analysis using substrates that yield fluorescent preci Enzymatic analysis using substrates that yield fluorescent preci

1991-08-23

1994-05-31

Wityshyn, Michael G.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

435 28, 435 23, 525 541, 546 33, 546109, 546153, 252 6251, 530300, 544289, 544249, C12Q 100, C08G 6348, A61K 3702, C04B 3500

Patent

active

053169069

ABSTRACT:
Novel fluorescent precipitating substrates made from a class of fluorophores, generally including quinazolinones (quinazolones), benzimidazoles, benzothiazoles, benzoxazoles, quinolines, indolines, and phenanthridines, having the general formula: ##STR1## where carbon atoms of --C.sup.1 .dbd.C.sup.2 -- are further joined so as to complete a first 5- or 6-membered aromatic ring which may contain at least one of the hetero atoms N, O or S,

REFERENCES:
patent: 3169129 (1965-02-01), Rodgers et al.
patent: 3526627 (1970-09-01), Brooks
patent: 3655664 (1972-04-01), Pater
patent: 5017475 (1991-05-01), Harte et al.
Hein et al; "The Use of Polyphosphoric Acid in the Synthesis of 2-Aryl-and 2-Alkyl-substituted Benzimidazoles, Benzoxazoles & Benzothiazoles"; J. Am. Chem. Soc. (79), 427 (1957).
Naumann & Langhals, "A Simple Synthesis of Dihydroxybipyriyls", Synthesis 279 (Apr. 1990).
Catalan et al, "Photoinduced Intramolecular Proton Transfer as the Mechanism of U V Stabilizers": A Reappraisal, J. Am. Chem. Soc. 112, 747 (1990).
Sinha et al; "Ground & Excited State Prototropic Reactions" in 2-(o-Hydroxyphenyl)Benzimidazole, Chem. Physics 102, 337 (1986).
Leary, et al., Proc Natl. Acad. Sci. 80, 4045 (1983).
Sinha & Dogra, Ground State and Excited State Prototropic Reactions in 2-(o-Hydroxyphenyl)benzimidazole, Chem. Physics 102, 337 (1986).
Orlando, et al., Red-and Near-infrared-luminescent Benzazole Derivatives, Chem. Comm. 23, 1551 (1971).
Williams & Heller, Intramolecular Proton Transfer Reactions in Excited Fluorescent Compounds, J. Phys. Chem. 74, 4473 (1970).
Biochem J 173, 723 (1976).
Wolf et al., Lab. Invest. 15, 1132 (1966) [Article Not Currently Available].
Menton, et al., Proc. Soc. Exp. Biol. Med. 51, 82 (1944) [Article Not Currently Available].
Ziomek, et al., Histochem. Cytochem. 38 (3), 437 (1990).
Springer, et al., Histochem. and Cytochem. 39, 231 (1991).
Hopman et al., Molecular Neuroanatomy, pp. 43, Elsevier Science Publishers (1988).
Stephens et al., J. Chem. Soc. 2971 (1949) [Article Not Currently Available].
Delegiorgiev, Dyes and Pigments, 12, 243 (1990) [Article Not Currently Available].
Kresze et al., Z. Naturforschung 10B, 370 (1955) [Article Not Currently Available].
Farley, et al., J. Biol. Chem. 225, 4680 (1980) [Article Not Currently Available].
Winkelman, et al., Am. J. Clin. Pathol. 57, 625, (1972) [Article Not Currently Available].
Flow Cytometry and Storting, Melamed, Lindmo and Mwendelsohn, Wiley-Liss (1990).
Capaldi and Hayashi, FEBS Lett 26, 4229-4238 (1972) [Article Not Currently Available].
Zhang, Lindorfer and Capaldi, Biochemistry, 27, 1389-1394 (1988).
Harlow and Lane, Antibodies, A Laboratory Manual, Cold Spring Harbor Lab (1988).
Stryer, L., Biochemistry, p. 189, W. H. Freeman and Company (1988).
Burstone, Enzyme Chemistry and its Applications in the Study of Neoplasm, p. 160, Academic Press (1962) [Article Not Currently Available].

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