Enhancement of GLP-2 activity of suppressing appetite

Details Enhancement of GLP-2 activity of suppressing appetite Enhancement of GLP-2 activity of suppressing appetite

2011-01-04

2011-01-04

Jiang, Dong (Department: 1646)

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Hormone or other secreted growth regulatory factor,...

C530S308000

Reexamination Certificate

active

07862824

ABSTRACT:
The effects of GLP-2 are enhanced using a GLP-1 activity inhibitor. For medical use to treat or inhibit the onset of medical conditions, disorder or diseases for which treatment with GLP-2 is indicated, the present invention provides a pharmaceutical combination comprising a GLP-2 activity enhancer, and a GLP-1 activity inhibitor. The combination is useful particularly to treat gastrointestinal conditions such as small bowel syndrome, mucositis and Crohn's disease, and to suppress appetite, for instance to treat obesity.

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Tang-Christensen et al., “The Proglucagon-derived peptide, glucagon-like peptide-2, is a neurotransmitter involved in the regulation of food intake”, Nature America, Inc. -, Nature Medicine, Jul. 2000, vol. 6, pp. 802-807.
Lovshin et al., “Glugan-like Peptide (GLP-2) Action in the Murine Central Nervous System Is Enhanced by Elimination of GLP-1 Receptor Signaling”, The Journal of Biological Chemistry, Jun. 2001, vol. 276, No. 24, pp. 21489-21499.

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