Enhanced replication of HCV RNA

Details Enhanced replication of HCV RNA Enhanced replication of HCV RNA

2007-02-27

2007-02-27

Campell, Bruce R. (Department: 1648)

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

C435S069100, C435S091400, C435S235100, C435S445000, C424S228100

Reexamination Certificate

active

10684846

ABSTRACT:
This invention provides methods of generating cells that stably replicate sub-genomic virus replicons. This invention also provides methods of generating cells that have disabled PKR activity and that stably replicate HCV sub-genomic replicons. The invention also provides methods of using the cells of the invention to screen for compounds that modulate viral RNA replication, including HCV RNA replication.

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