Enhanced indole biosynthesis

Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for...

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435122, 435 691, 435 711, 435156, 4351723, 4352402, 4352523, 43525233, 43525234, 4353201, 536 221, 536 231, 536 232, 536 237, C12N 900, C12N 120, C12P 722, C12P 1710

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054948169

ABSTRACT:
DNA molecules encoding a modified tryptophan synthase beta subunit are disclosed. When expressed in a recombinant host microorganism, these polypeptide analogs enable significant levels of intracellular indole production and accumulation. In the presence of an aromatic dioxygenase enzyme, the indole so produced can be converted to indoxyl, which upon exposure to air oxidizes to indigo.

REFERENCES:
Yanofsky et al., "The effects of deletions, point mutations, reversions and suppressor mutations on the two components of the tryptophan synthetase of Escherichia coli," P.N.A.S. 45:1016-1026 (1959).
Bang et al., "Production of L-Tryptophan by Escherichia coli Cells", Biotech & Bioengineering vol. 25, pp. 999-1011 (1993).
Cotton et al., "Tryptophan Synthetase .beta..sub.2 subunit," Journal of Biological Chemistry, vol. 247, No. 6, pp. 1883-1891, (1972).

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