Endothelin receptor antagonists

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514312, 546 90, 546153, 546154, 546156, 546157, C07D215227, C07D21520, A61K 3147

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active

057313210

ABSTRACT:
Novel compounds of the formula I ##STR1## in which --Y--Z--, R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 have the meanings as stated in the specification, and their salts show endothelin receptor antagonist properties.

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patent: 5514691 (1996-05-01), Chan et al.
patent: 5565472 (1996-10-01), Hamanaka et al.
Fehnel, Edward A., "Friedlander Syntheses with o-Aminoaryl Ketones . . ", J. Heterocyclic. Chem., vol. 4, No. 4, 1967, pp. 565-570.
Derwent Abstract of JP 6 340 658, 1994.
Matsumori et al., Chemical Abstracts 79:5234v, 1973.

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