Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Tripeptides – e.g. – tripeptide thyroliberin – etc.
Patent
1990-02-28
1992-05-19
Russel, Jeffrey E.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
Tripeptides, e.g., tripeptide thyroliberin , etc.
2609982, 514 18, 514 19, 530345, 548537, A61K 3702, C07K 506, C07K 508
Patent
active
051150980
ABSTRACT:
A C- and N-blocked prolyl-alanine compound having the structure ##STR1## in which X is --OCH.sub.2 --B or ##STR2## in which A and B are hydrogen or phenyl and Y is isobutyl inhibits binding capacity of GP120 and inhibits infection of cells by HIV-1.
REFERENCES:
patent: 4093713 (1978-06-01), Lestany et al.
patent: 4416871 (1983-11-01), Walter et al.
patent: 4456594 (1984-06-01), Pfeiffa
patent: 4985406 (1991-01-01), Charpentier et al.
CA102:3717416, "Structural Study of benzyloxy Carbonyl Prolyl alanyl MeOne tert-butyl ester", (1985).
"Potential anlinal agents: Carbobenzoxy di-Tripeptides", Nicolardes et al., vol. 11:76-79 (Jul. 1967).
Miller et Conf. "Anunal Activity polyl Carbobenzoxy di-Tripeptides on measles inus:Applied Miciobologic", 1489-1496.
CA87:53571q Theoretical Confanalysis on cyclo molyl phenylalanyl peptides, Ajo et al. (1977).
Methoden Der Organischen Chemie (Houben-Weyl), Muller, Georg Thieme Verlag Stuttgart, 1974, p. 328.
Smith et al.; Blocking of HIV-1 Infectivity by a Soluble, Secreted Form of the CD4 Antigen; Science; 238:1704-1707; (Dec. 1987).
Fisher et al.; HIV infection is Blocked in vitro by Recombinant Soluble CD4; Nature; 331:76-78 (Jan. 1988).
Hussey et al.; A Soluble CD4 Protein Selectively Inhibits HIV Replication and Syncytium Formation; Nature; 331:78-81; (Jan. 1988).
Deen et al.; A Soluble Form of CD4 (T4) Protein Inhibite AIDS Virus Infection; Nature 331:82-84; (Jan. 1988).
Traunecker et al.; Soluble CD 4 Molecules Neutralize Human Immunodeficiency Virus Type 1; Nature; 331:84-86; (Jan. 1988).
Capon et al.; Designing CD4 Immunoadhesins for AIDS Therapy; Nature 337:525-531; (Feb. 1989).
Traunecker et al.; Highly Efficient Neutralization of HIV with Recombinant CD4-Immunoglobulin Molecules; Nature; 339:68-70; (May 1989).
Larder et al,; HIV with Reduced Sensitivity to Zidovudine (AZT) Isolated During Prolonged Therapy; Science; 243:1731-1734; (Mar. 1989).
Larder et al.; Multiple Mutations in HIV-1 Reverse Transcriptase Confer High-Level Resistance to Zidovudine (AZT) Science: 246:155-1158 (Dec. 1989).
Jameson et al.; Location and Chemical Synthesis of a Binding Site for HIV-1 on the CD 4 Protein; Science; 240:1355-1339; (Jun. 1988).
Lifson et al.; Synthetic CD4 Peptide Derivatives that Inhibit HIV Infection and Cytopathicity; Science; 241:712-716; (Aug. 1988).
Nara et al.; CD4 antigen-based Antireceptor Peptides Inhibit Infectivity of Human Immunodeficiency Virus in vitro at Multiple Stages of the Viral Life Cycle: Proc. Natl.; 86:7139-7143 (Sep. 1989).
Baba et al.; Mechanism of Inhibitory Effect of Dextran Sulfate and Heparin on Replication of Human Immuodeficiency Virus in vitro; Proc. Natl. Acad. Sci.; 85:6132-6136 (Aug. 1988).
Mitsuya et al.; Dextran Sulfate Suppression of Viruses in the HIV Family: Inhibition of Virion Binding to CD4.sup.+ Cells; Science; 240:646-649 (Apr. 1988).
Miller et al.; Antiviral Activity of Carbobenzoxy Di-and Tripeptides on Measles Virus; Applied Microbiology; 16:1489-1496; (Oct. 1968).
Burley et al.; Aromatic-Aromatic Interaction: A Mechanism of Protein Structure Stabilization; Science; 229:23-28; (Jul. 1985).
Nicolaides et al.; Potential Antiviral Agents, Carbobenzoxy Di-and Tripeptides Active against Measles and Herpes Viruses; II:74-79; (Jul. 1967).
Burakoff Steven J.
Schreiber Stuart L.
Dana-Farber Cancer Institute Inc.
President and Fellows of Harvard College
Russel Jeffrey E.
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