Derivatives of 2', 5'-oligoadenylate and antiviral uses thereof

Details Derivatives of 2', 5'-oligoadenylate and antiviral uses thereof Derivatives of 2', 5'-oligoadenylate and antiviral uses thereof

1988-01-11

1989-08-22

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 28, 536 29, C07H 2100

Patent

active

048597686

ABSTRACT:
Synthetic analogs of 2',5'-oligoadenylate wherein the aglycon, ribosyl moiety and/or terminal nucleoside have been modified are effective antiviral agents for pharmaceutical and agricultural use. They are particularly useful in inhibiting replication of tobacco mosaic virus. Novel synthetic analogs have the following formulae wherein m=0, 1, 2 and 3 and n=0, 1, 2, 3 or 4: ##STR1##

REFERENCES:
patent: 4464359 (1984-08-01), Suhadolnik et al.
patent: 4654326 (1987-03-01), Devash
Swai et al., The Journal of Biochemistry 258, No. 3, pp. 1671-1677, (1983).
Charubala et al., Tetrahedron Letters 21, pp. 4077-4080, (1980).
Eppstein et al., Virology 131, pp. 341-354, (1983).
Goswami et al., The Journal of Biochemistry 257, No. 12, pp. 6867-6870, (1982).
Devash et al., The Journal of Biological Chemistry 259, No. 6, pp. 3482-3486, (1984).

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