Emulsifying compositions for suppository bases and suppositories

Details Emulsifying compositions for suppository bases and suppositories Emulsifying compositions for suppository bases and suppositories

1988-03-24

1989-10-03

Kight, John

Drug, bio-affecting and body treating compositions

Designated organic nonactive ingredient containing other...

Carboxylic acid ester

514966, 514969, 424502, 424DIG15, 604288, A61K 902

Patent

active

048717770

ABSTRACT:
A composition for suppository bases consisting of a water-insoluble fat and an adduct of 5 to 50 mol ethylene oxide with 1 mol hardened castor oil as emulsifier enables suppositories containing aqueous active-principle solutions to be prepared. The emulsifier is preferably present in a quantity of 0.2 to 10% by weight. Suppositories containing up to 30% by weight water dispersed therein can be prepared using the above composition.

REFERENCES:
patent: 4368185 (1983-01-01), Mizuno et al.
Chem. Abstract 95:30401k.
Chem. Abstract 88:158485p.
Chem. Abstract 98:221748a.
Chem. Abstract 105:48957f.
Suppositorien by Prof. Dr. Bernd. W. Muller, 1986, pp. 94-101, DAB 9, 1986.
Europaisches Arzneibuch by Prof. Dr. Dr. h.c. H. Bohme and Prof. Dr. K. Hartke, pp. 248-252.

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