Ellipticine derivative and process for preparing the same

Details Ellipticine derivative and process for preparing the same Ellipticine derivative and process for preparing the same

1995-05-24

1997-02-25

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

540 70, A61K 31435, C07D47104

Patent

active

056059043

ABSTRACT:
An ellipticine derivative of the formula [I]: ##STR1## wherein R is a substituted lower alkyl group, a substituted or unsubstituted lower alkoxy group or a heteromonocyclic group, or a pharmaceutically acceptable salt thereof, which show excellent antitumor activity, less side effects, less toxicity and/or high solubility in water and are useful as antitumor agent, and a process for preparing the same.

REFERENCES:
patent: 3933827 (1976-01-01), Brossi et al.
patent: 4310667 (1982-01-01), Le Pecq et al.
patent: 5272146 (1993-12-01), Haugwitz
Merck Index, 10th Ed. p. 3511 (1983).
Brossi, ed. The Alkaloids vol. XXV Academic Press, NY, 1985, p. 141.
Ratcliffe et al. Jour. Chem. Soc. Perkin I, (1988) pp. 2933-2943.

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