Process for producing .beta.-aminoalcohols compounds

Details Process for producing .beta.-aminoalcohols compounds Process for producing .beta.-aminoalcohols compounds

1995-03-09

1996-11-26

Davis, Zinna Northington

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546147, C07D40106

Patent

active

055787304

ABSTRACT:
A process for the production of a .beta.-aminoalcohol 2-[3(S)-amino-2-hydroxy-4-phenylbutyl]-N-tert.butyl-decahydro-(4aS,8aS)-is oquinoline-3(S)-carboxamide of the formula ##STR1## via the oxazolidinone corresponding to the aminoalcohol 10 which process comprises refluxing a sulphonic acid ester with a carboxamide in the presence of a base and a solvent.

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patent: 5236783 (1993-10-01), Gokhale et al.
March, Advanced Organic Chemistry, 3rd Edition, 1985, pp. 311-312.
Melon, et al, Enantiomerically pure 3-amino-2-hydroxy and 5-amino-4-hydroxy acids from D-isoascorbic acid, Bull Soc. Chim Fr, vol. 129, pp. 585-593 (1992).
Iizuka, et al, Orally Potent Human Renin Inhibitors Derived from Angiotensinogen Transition State: Design, Synthesis, and Mode of Interaction, J. Med. Chem. vol. 33, pp. 2707-2714 (1990).

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