Elastase inhibitory polypeptide and process for production there

Details Elastase inhibitory polypeptide and process for production there Elastase inhibitory polypeptide and process for production there

1992-10-20

1998-12-22

Teng, Sally

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530324, 435 692, A61K 3816, C12N 1541, C07K 1481

Patent

active

058519831

ABSTRACT:
The present invention provides an elastase inhibitory polypeptide comprising a C-terminal half of a human secretory leukocyte protease inhibitor (SLPI) and having an elastase inhibitory activity wherein inhibitory activity of a trypsin-like serine protease does not exceed 1/10 of elastase inhibitory activity, and polypeptides having the above-mentioned biological activity wherein one or more than one amino acid is added, one or more than one amino acid is deleted and/or one or more than one amino acid is replaced. The present invention also provides a process for the production of the above-mentioned protein or other protein via a corresponding fused protein.

REFERENCES:
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patent: 4845076 (1989-07-01), Heinzel et al.
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