Organic compounds -- part of the class 532-570 series – Organic compounds – Unsubstituted hydrocarbyl chain between the ring and the -c-...
Patent
1993-12-02
1995-12-26
Daus, Donald G.
Organic compounds -- part of the class 532-570 series
Organic compounds
Unsubstituted hydrocarbyl chain between the ring and the -c-...
C07D51522
Patent
active
054789320
ABSTRACT:
Ecteinascidins (Et's), isolated from the Caribbean tunicate Ecteinascidia turbinata, protect mice in vivo against P388 lymphoma, B16 melanoma, M5076 ovarian sarcoma, Lewis lung carcinoma, and the LX-1 human lung and MX-1 human mammary carcinoma zenografts.
REFERENCES:
patent: 5089273 (1992-02-01), Rinehart et al.
patent: 5149804 (1992-09-01), Rinehart et al.
patent: 5256663 (1993-10-01), Rinehart et al.
Guan et al Jour. Biomolec. Struc. & Dynam. vol. 10 pp. 793-817 (1993).
Sakai et al. Proc. Natl. Acad. Sci. USA vol. 89 pp. 11456-11460 (1992).
Guan et al, Chem. Abstr vol. 119 Entry 160608 (1993).
Sakai et al, Chem. Abstr vol. 118 Entry 160639 (1992).
Shamma et al., Carbon-13 NMR Shift Assignments of Amines and Alkaloids, p. 206 (1979).
Lown et al., Biochemistry, 21, 419-428 (1982).
Zmijewski et al., Chem. Biol. Interactions, 52, 361-375 (1985).
Ito, CRC Crit. Rev. Anal. Chem., 17, 65-143 (1986).
Rinehart et al., "Topics in Pharmaceutical Sciences 1989" pp. 613-626, D. D. Breimer, D. J. A. Cromwelin, K. K. Midha, Eds., Amsterdam Medical Press B.V., Noordwijk, The Netherlands (1989).
Rinehart et al., Biological Mass Spectrometry, 233-258 eds. Burlingame et al., Elsevier Amsterdam (1990).
Rinehart et al., Pure & Appl. Chem., vol. 62, No. 7, pp. 1277-1280 (1990).
Rinehart et al., Journal of Natural Products, vol. 53, No. 4, pp. 771-792 (1990).
Rinehart et al., J. Org. Chem., 55, 4512-4515 (1990).
Wright et al., J. Org. Chem., 55, 4508-4512 (1990).
Rinehart Kenneth L.
Sakai Ryuichi
Daus Donald G.
Linek Ernest V.
The Board of Trustees of the University of Illinois
LandOfFree
Ecteinascidins does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Ecteinascidins, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Ecteinascidins will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1369977