Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1996-06-26
2000-01-04
Kemmerer, Elizabeth
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
4352523, 4353201, 536 235, 530350, C12P 2100, C12N 121, C12N 1500, C07K 1446
Patent
active
060108746
ABSTRACT:
This invention and relates to polynucleotide and polypeptide sequences of the Early Onset Alzheimer's Disease gene (herein "EOAD gene"). More particularly, this invention relates to fragments and mutants EOAD gene useful as probes and amplification primers for the identification of a predisposition or diagnosis of Alzheimer's Disease.
REFERENCES:
patent: 5449604 (1995-09-01), Schellenberg et al.
Hillier et al. GenBank. Accession No. R05907. Apr. 3, 1995.
Mullan, M. et al., "A locus for familial early-onset Alzheimer's disease on the long arm of chromosome 14, proximal to the .alpha.1-antichymotrypsin gene", Nature Genet., 1992, 2:340-342.
Mullan, M. et al., "Clinical Features of Early Onset, Familial Alzheimer's Disease Linked to Chromosome 14", Am. J. of Med. Genet., 1995, 60:44-52.
Schellenberg, G.D. et al., "Chromosome 14 and Late-Onset Familial Alzheimer Disease (FAD)", Am. J. Hum. Genet., 1993, 53:619-628.
Schellenberg, G.D. et al., "Genetic Linkage Evidence for a Familial Alzheimer's Disease Locus on Chromosome 14", Science, 1992, 258:668-671.
Sherrington, R. et al., "Cloning a gene bearing missense mutations in early-onset familial Alzheimer's disease", Nature, 1995, 375:754-760.
St. George-Hyslop, P. et al., "Genetic evidence for a novel familial Alzheimer's disease locus on chromosome 14", Nature Genet., 1992, 2:330-334.
Van Broeckhoven, C. et al., "Mapping of a gene predisposing to early-onset Alzheimer's disease to chromosome 14q24.3", Nature Genet., 1992, 3:335-339.
Strom et al. A yeast GTPase-activating protein that interacts specifically with a member of the Ypt/Rab family. Nature 361:736-739 (Feb. 25, 1993).
Han William T.
Kemmerer Elizabeth
King William T.
Romeo David S.
University of South Florida
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