E6 binding proteins

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving virus or bacteriophage

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

435 723, 435 76, 435 77, 435 771, 435 772, 435 792, 530300, 530350, 536 2372, 536 235, 514 12, 930220, C12Q 170, G01N 33574, A61K 3800, C07H 2104

Patent

active

059898046

ABSTRACT:
E6-BP polypeptides, nucleic acids encoding E6-BP polypeptides, and uses thereof.

REFERENCES:
patent: 5532348 (1996-07-01), Huibregtse et al.
Hartman et al., "The complete primary structure of rat chaperonin 10 reveals a putative .beta..alpha..beta. nucleotide-binding domain with homology to p21ras ", Biochimica et Biophysica Acta 1164:219-222 (1993).
Ryan et al., "Isolation of a cDNA clone specifying rat chaperonin 10, a stress-inducible mitochondrial matrix protein synthesised without a cleavable presequence", FEBS Letters, 337:152-156 (Jan 1994).
Chen et al., "Interaction of papillomavirus E6 oncoproteins with a putative calcium-binding protein" Science 269:529-531 (1995).
Weis et al., "The endoplasmic reticulumcalcium-binding protein of 55 kDA is a novel EF-hand protein retained int eh endoplasmic reticulum by a carboxyl-terminal His-Asp-Glu-Leu motif" J. Biological Chemistry 269:19142-19150 (1994).
Arbeit, J.M. et al., "Neuroepithelial Carcinomas in Mice Transgenic with Human Papillomavirus Type 16 E6/E7 ORFs" Am. J. Pathol., vol. 142, No. 4, pp. 1187-1197, 1993.
Chien, C.--T. et al., "The two-hybrid system: A method to identify and clone genes for proteins that interact with a protein of interest" Proc. Natl. Acad. Sci., vol. 88, pp. 9578-9582, Nov. 1991.
Cole, S.T. and O. Danos, "Nucleotide Sequence and Comparative Analysis of the Human Papillomavirus Type 18 Genome" J. Mol. Biol., vol. 193, pp. 599-608, 1987.
Crook, T. et al., "Degradation of p53 Can be Targeted by HPV E6 Sequences Distinct from Those Required for p. 53 Binding and Trans-Activation" Cell, vol. 67, pp. 547-556, 1991.
Fields, S. and O. Song, "A novel genetic system to detect protein-protein interactions" Nature, vol. 336, pp. 495-496, 1988.
Kaebling, M. et al., "Loss of heterozygosity on chromosome 17p and mutant p53 in HPV-negative cervical carcinomas" The Lancet, vol. 340, pp. 140-142, Jul. 18, 1992.
Gu, Z. et al., "DNA damage induced p53 mediated transcription is inhibited by human papillomavirus typ 18 E6" Oncogene, vol. 9, pp. 629-633, 1994.
Hoppe-Seyler, F. and K. Butz, "Cellular Control of Human Papillomavirus Oncogene Transcription" Molecular Carcinogenesis, vol 10, pp. 134-141, 1994.
Howley, P.M., "Role of the Human Papillomavirus in Human Cancer" Cancer Research (Suppl.), vol. 51. pp. 5019s-5022s, Sep. 15, 1991.
Huibregtse, J.M. et al., "A cellular protein mediates association of p53 with the E6 oncoprotein of human papillomavirus types 16 or 18" The EMBO Journal, vol. 10, No. 13, pp. 4129-4135, 1991.
Huibregtse, J.M. et al., "Cloning and Expression of the cDNA for E6-AP, a Protein That Mediates the Interaction of the Human Papillomavirus E6 Oncoprotein with p53" Molecular and Cellular Biology, vol 13, No. 2, pp. 775-784, Feb. 1993.
Kim, K. H. et al., "Expression and Localization of Human Papillomavirus Type 16 E6 and E7 Open Reading Frame Proteins in Human Epidermal Keratinocyte" Yonsei Medical Journal, vol. 35, No. 1, pp. 1-9, 1994.
Lamberti, C. et al., "Transcriptional activation by the papillomavirus E6zinc finger oncoprotein" The EMBO Journal, vol. 9, No. 6, pp. 1907-1913, 1990.
Lechner, M.S. et al., "Inhibition of p53 DNA Binding by Human Papillomavirus E6 Proteins" Journal of Virology, vol. 68, No. 7, pp. 4262-4273, Jul. 1994.
Liang, X.H. et al., "Co-localization of the tumor-suppressor protein p53 and human papillomavirus E6 protein in human cervical carcinoma cell lines" Oncogene, vol. 8, pp. 2645-2652, 1993;.
May, E. et al., "Endogenous HeLa p53 proteins are easily detected in HeLa cells transfected with mouse deletion mutant p53 gene" Oncogene, vol. 6, pp. 1363-1365, 1991.
Mietz, J.A. et al., "The transcriptional transactivation function of wild-type p53 is inhibited by SV40 large T-antigen and by HPV-16 E6 oncoprotein" The EMBO Journal, vol. 11, No. 13, pp. 5013-5020, 1992.
Morrissey, L.C. et al., "trans Activation by the Bovine Papillomavirus E2 Protein in Saccharomyces cerevisiae" Journal of Virology, vol. 63, No. 10, pp. 4422-4425, Oct. 1989.
Scheffner, M. et al., "The E6 Oncoprotein Encoded by Human Papillomavirus Types 16 and 18 Promotes the Degradation of p53" Cell, vol. 63, pp. 1129-1136, Dec. 21, 1990.
Scheffner, M. et al., "The HPV-16 E6 and E6-AP Complex Functions as a Ubiquitin-Protein Ligase in the Ubiquitination of p53" Cell, vol. 75, pp. 495-505, Nov. 5, 1993.
Scheffner, N. et al., "Interaction of the Human Papillomavirus Type 16 E6 Oncoprotein with Wild-Type and Mutant Human p53 Proteins" Journal of Virology, vol. 66, No. 8, pp. 5100-5105, Aug. 1992;.
Sedman, S.A. et al., "Mutant p53 Can Substitute for Human Papillomavirus Type 16 E6 in Immortalization of Human Keratinocytes but Does Not have E6-Associated trans-Activation or Transforming Activity" Journal of Virology, vol. 66, No. 7, pp. 4201-4208, Jul. 1992.
Storey, A. and L. Banks, "Human papvillomavirus type 16 E6 gene cooperates with EJ-ras to immortalize primary mouse cells" Oncogene, vol. 8, pp. 919-924, 1993.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

E6 binding proteins does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with E6 binding proteins, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and E6 binding proteins will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1220052

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.