Dolastatin 15 derivatives with carbonyl and heterocyclic functio

Details Dolastatin 15 derivatives with carbonyl and heterocyclic functio Dolastatin 15 derivatives with carbonyl and heterocyclic functio

1997-03-10

1999-10-12

Huff, Sheela

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530330, 530329, 514 18, C07K 500

Patent

active

059655372

ABSTRACT:
The present invention relates to novel peptides useful as anti-cancer agents. The compounds of the invention are of Formula I,

REFERENCES:
patent: 4816444 (1989-03-01), Pettit et al.
patent: 5502032 (1996-03-01), Haupt et al.
patent: 5504191 (1996-04-01), Pettit et al.
patent: 5530097 (1996-06-01), Pettit et al.
patent: 5554725 (1996-09-01), Pettit
Morrison and Boyd, Organic Chemistry pp. 1004-1006, 1973.
Pettit, G. R., et al., "The Isolation and Structure of a Remarkable Marine Animal Antineoplastic Constituent: Dolastatin 10", J. Am. Chem. Soc. 109: 6883-6885 (1987).
Bai, R., et al., "Structure-Activity Studies with Chiral Isomers and with Segments of the Antimitotic Marine Peptide Dolastatin 10", Biochemical Pharmacology 40(8): 1859-1864 (1990).
Pettit, G. R., et al., "Antineoplastic Agents. 220. Synthesis of Natural (-)-Dolastatin 15", J. Am. Chem. Soc., 113: 6692-6693 (1991).
Bai, R., et al., "Dolastatin 15, a potent antimitotic depsipeptide derived from Dolabella auricularia. Interaction with tubulin and effects on cellular microtubules", 1-Pharmacology Abstract 117: 103735g p. 41 (1992).
Pettit, G. R., et al., "Isolation and Structure of the Cytostatic Depsipeptide Dolastatin 13 from the Sea Hare Dolabella auricularia", J. Am. Chem. Soc., 111(13): 50115-5017 (1989).
Pettit, G. R., et al., "Antineoplastic Agents 337. Synthesis of Dolastatin-10 Structural Modifications," Anti-Cancer Drug Design, 10: 529-544 (1995).
Miyazaki, K., et al., "Synthesis and Antitumor Activity of Novel Dolastatin-10 Analogs," Chem. Pharm. Bull., 43(10): 1706-1718 (1995).
Pettit, G. R., et al., "Isolation and Structure of the Cytostatic Linear Depsipeptide Dolastatin 15", J. Org. Chem., 54: 6005-6006 (1989).
Pettit, G.R. et al., "The Dolastatins 20. A convenient Synthetic Route to Dolastatin 15", Tetrahedron, 50(42):12097-12108 (1994).
Pettit, G.R. et al., Isolation of Dolastatins 10-15 From the Marine Mollusc Dolabella Auricularia, Tetrahedron, 49(42):9151-9170 (1993).

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