DNA sequences encoding fusion proteins comprising GM-CSF and IL-

Details DNA sequences encoding fusion proteins comprising GM-CSF and IL- DNA sequences encoding fusion proteins comprising GM-CSF and IL-

1991-03-22

1992-04-28

Draper, Garnette D.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

4353201, 4351723, 435 695, 435 6952, 536 27, C12N 1562, C12N 1563, C07H 2104

Patent

active

051089106

ABSTRACT:
A DNA sequence encoding fusion protein is disclosed which comprises GM-CSF and IL-3. Such fusion proteins more biologically active than GM-CSF or IL-3 alone or GM-CSF and IL-3 combined.

REFERENCES:
patent: 4935233 (1990-06-01), Bell et al.
patent: 5032395 (1991-07-01), Clark et al.
Exp. Hematol. 15, 1007-1012, 1987, Williams et al. Interactions between Purified Murine Colony-Stimulating Factors on the in vitro proliferation of Purified Murine Granulocytes.
PNAS 88; 5809-5813, Jul. 1991, Curtis et al., Enhanced hematopoietic activity of a human granulocyte/macrophage colony stimulating factor-interleukin 3 fusion protein.
Donahue et al., Human IL-3 and GM-CSF Act Synergistically in Stimulating Hematopoiesis in Primates, Science 241:1820, 1988.
Broxmeyer et al., Synergistic myelopoietic actions in vivo after administration to mice of combinations of purified natural murine colony-stimulating factor 1, recombinant murine interleukin 3, and recombinant murine granulocyte/macrophage colony-stimulating factor, Proc. Natl. Acad. Sci. USA 84:3871, 1987.
Krumwieh et al., Human Recombinant Derived IL-3 and GM-CSF in Hematopoiesis of Normal Cynomolgus Monkeys, Behring Inst. Mitt. 83:250, 1988.
Park et al., Heterogeneity in Human Interleukin-3 Receptors, J. Biol. Chem. 264:5420, 1989.
Yang et al., The Human Genes for GM-CSF and IL 3 are Closely Linked in Tandem on Chromosome 5, Blood 71: 958, 1988.
Barlow et al., Close genetic and physical linkage between the murine haemopoietic growth factor genes GM-CSF and Multi-CSF (IL3), EMBO J. 6:617 1987 .
Kelso et al., Independent Regulation of Granulocyte-Macrophage Colony-Stimulating Factor and Multi-Lineage Colony-Stimulating Factor Production in T Lymphocyte Clones, J. Immunol. 136:1718, 1986.

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