DNA-PK inhibitors

Details DNA-PK inhibitors DNA-PK inhibitors

2008-06-05

2010-06-08

Shameem, Golam M (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C549S029000, C549S041000, C549S043000, C514S438000

Reexamination Certificate

active

07732483

ABSTRACT:
A compound of formula I:and isomers, salts, solvates, chemically protected forms, and prodrugs thereof, wherein: R1and R2are independently selected from hydrogen, an optionally substituted C1-7alkyl group, C3-20heterocyclyl group, or C5-20aryl group, or may together form, along with the nitrogen atom to which they are attached, an optionally substituted heterocyclic ring having from 4 to 8 ring atoms; Q is —NH—C(═O)— or —O—; Y is an optionally substituted C1-5alkylene group; X is selected from SR3or NR4R5, wherein, R3, or R4and R5are independently selected from hydrogen, optionally substituted C1-7alkyl, C5-20aryl, or C3-20heterocyclyl groups, or R4and R5may together form, along with the nitrogen atom to which they are attached, an optionally substituted heterocyclic ring having from 4 to 8 ring atoms; if Q is —O—, X is additionally selected from —C(═O)—NR6R7, wherein R6and R7are independently selected from hydrogen, optionally substituted C1-7alkyl, C5-20aryl, or C3-20heterocyclyl groups, or R6and R7may together form, along with the nitrogen atom to which they are attached, an optionally substituted heterocyclic ring having from 4 to 8 ring atoms; and if Q is —NH—C(═O)—, —Y—X may additionally be selected from C1-7alkyl.

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