Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1993-12-10
1997-01-28
Ulm, John
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
4352523, 4353201, 435 697, 530350, 536 235, 536 243, 536 234, C12N 510, C12N 1512, C07K 14705, C22N 1562
Patent
active
055977057
ABSTRACT:
The present invention provides a recombinant expression system for production of functional thyroid hormone receptor protein(s). The invention also provides a method to produce thyroid hormone receptor protein(s) by culturing the cells of the invention recombinant expression system. Also provided are thyroid hormone receptor protein(s) produced by the invention method. In addition, the present invention provides recombinant DNAs comprised of sequences which encode proteins having the hormone-binding and/or transcription-activating characteristics of a thyroid hormone receptor. The invention also provides various plasmids containing receptor sequences which exemplify the DNAs of the invention. The invention further provides complementary mRNAs, cells transformed with invention DNAs, and nucleic acid probes derived from invention DNAs.
REFERENCES:
J. Biol. Chem 260:2515-2526, 25 Feb. 1985, Lubahn et al. Electrophoretic Characterization of Purified Porcine, Murine, Rat, and Human Uterine Estrogen Receptors.
Eur. J. Biochem. 139:613-617 (1984), Heintz et al Purification of chick nuclear thyroid-hormone-receptor protein.
P.N.A.S. 82:7889-7893, Dec. 1985, Walter et al Cloning of the human estrogen receptor cDNA.
Nature 311:626-631, 18 Oct. 1984, Leonard et al. Molecular cloning and expression of cDNAs for the human interleukin-2 receptor.
Arriza Jeffrey
Evans Ronald M.
Giguere Vincent
Hollenberg Stanley M.
Ong Estelita S.
Raymer Gregory P.
Reiter Stephen E.
The Salk Institute for Biological Studies
Ulm John
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