Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1994-12-12
1999-09-28
Smith, Lynette F.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
530350, 424 851, 4241841, C12Q 168, C07K 100, A61K 4505, A61K 3938
Patent
active
059586788
ABSTRACT:
A single-stranded nucleic acid molecule which encodes an amino acid sequence comprising at least a portion of a T4 glycoprotein is provided. Additionally, amino acid sequences which comprise at least a portion of a T4 glycoprotein and are useful as a prophylaxis for treating a subject with acquired immune deficiency syndrome are provided. These amino acid sequences, which are capable of specifically forming a complex with a human immunodeficiency virus envelope glycoprotein and which are soluble in an aqueous solution may be administered to a subject infected with a human immunodeficiency virus so as to block the human immunodeficiency virus from binding to T4.sup.+ cells.
Monoclonal antibodies directed to the water-soluble amino acid sequences of the present invention may be used as vaccines for immunizing a subject against acquired immune deficiency syndrome.
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Axel Richard
Chess Leonard
Littman Dan R.
Maddon Paul J.
McDougal J. Steven
Smith Lynette F.
The Trustees of Columbia University in the City of New York
White John P.
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