Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1994-04-08
2000-08-29
Myers, Carla J.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
435471, 435455, 435183, 435219, 435226, 4352523, 4353201, 536 231, 536 232, 536 235, 536 2431, C12N 1500, C12N 1563, C12N 120, C07H 2104
Patent
active
061107018
ABSTRACT:
A complementary DNA (cDNA) encoding full length form of ICE.sub.rel -II is identified, sequenced and isolated. The cDNA is cloned into expression vectors for expression in recombinant hosts. The cDNA is useful to produce recombinant full length ICE.sub.rel -II. The cDNA and the recombinant ICE.sub.rel -II protein derived therefrom are useful in diagnostic kits, laboratory reagents and assays. The cDNA and the recombinant ICE.sub.rel -II protein may be used to identify compounds that affect ICE.sub.rel -II function, inflammation and cell apoptosis. ICE.sub.rel -II function, inflammation and cell apoptosis may also be modulated by ICE.sub.rel -II antisense or gene therapy.
REFERENCES:
patent: 5416013 (1995-05-01), Black et al.
Barinaga, M. "Cell Suicide: by ICE, Not Fire", Science, vol. 263, Feb. 11, 1994 pp 754-756.
Cerretti, D.P. et al. "Molecular Cloning of the Interleukin-1beta concerting Enzyme", Science, vol. 256, Apr. 3, 1992 pp 97-100.
Gagliardini, V. et al., "Prevention of Vertebrate Neuronal Death by the crmA Gene", Science, vol. 263, Feb. 11, 1994, pp 826-828.
Miura, M. et al., "Induction of Apoptosis in Fibroblasts by IL-1Beta-Converting Enzyme, a Mammalian Homolog of the C. elegans Cell Death Gene ced-3", Cell, vol. 75, Nov. 19, 1993, pp. 653-660.
Thornberry, N.A. et al. "A Novel Heterodimeric Cysteine Protease is Required for Interleukin-1Beta Processing in Monocyles", Nature, vol. 356, Apr. 30, 1992, pp 768-774.
Yuan, J. et al., "The C. elegans Cell Death Gene ced-3 Encodes of Protein Similar to Mammalian Interleukin 1Beta-Converting Enzyme", Cell, vol. 75, Nov. 19, 1993, pp 641-652.
Ali Ambereen
Munday Neil A.
Nicholson Donald W.
Vaillancourt John P.
Coppola Joseph A.
Merck Frosst Canada & Co.
Myers Carla J.
Tribble Jack L.
LandOfFree
DNA encoding precursor of interleukin-1.beta. converting enzyme- does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with DNA encoding precursor of interleukin-1.beta. converting enzyme-, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and DNA encoding precursor of interleukin-1.beta. converting enzyme- will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1248535