DNA encoding histidyl tRNA synthetase variant from Streptococcus

Details DNA encoding histidyl tRNA synthetase variant from Streptococcus DNA encoding histidyl tRNA synthetase variant from Streptococcus

1997-08-06

1998-08-18

Prouty, Rebecca E.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

435 6, 4353201, 4352523, 43525411, 435325, 536 232, 536 243, C12N 900, C12N 1500, C12N 120, C07H 2104

Patent

active

057957584

ABSTRACT:
The invention provides hisS polypeptides and DNA (RNA) encoding hisS polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing hisS polypeptides to screen for antibacterial compounds.

REFERENCES:
R. Calendar et al., "Purification and Physical Characterization of Tyrosyl Ribonucleic Acid Synthetases from Escerichia coli and Bacillus subtilis", Biochemistry, 5(5) pp. 1681-1690 (1966).
J. Hughes et al., "How Does Pseudomonas Fluorescens, the Producing Organism of the Antibiotic Pseudomonic Acid A, Avoid Suicide?", FEBS Letters, 122(2) pp. 322-324 (1980).
Menguito et al., "Molecular Cloning, Sequence, Structural Analysis and Expression of the Histidyl-tRNA Synthetase Gene from Streptococcus equisimilis," Nucleic Acids Researc, 21(3) pp. 615-620 (1993).
Von Der Haar et al., "Target Directed Drug Synthesis: The Aminoactyl-tRNA Synthetases as Possible Targets," Angewandte Chemie, 20(3) pp. 217-223 (1981).
Meinnel et al., "Aminoacyl-tRNA Synthetases: Occurrence, Structure, and Function," In: tRNA: Structure, Biosynthesis , and Function, American Society for Microbiology, pp. 251-292 (1985).
Delorme et al., "Histidine Biosynthesis Genes in Lactococaus lactis subsp. lactis", Journal of Bacteriology, 174(20), pp. 6571-6579 (1992).
Accession No. Z17214, Feb. 12, 1993, Menguito et al., Molecular cloning, sequence, structural analysis and expression of the histidyl-tRNA synthetase gene from Streptococcus esquisimilis.
Accession No. 267058, Jun. 1, 1994, Menguito et al., Molecular cloning, sequence, structural analysis and expression of the histidyl-tRNA synthetase gene from Streptococcus equisimilis.

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