DNA encoding a protein-coupled receptor kinase

Details DNA encoding a protein-coupled receptor kinase DNA encoding a protein-coupled receptor kinase

1992-11-30

1994-11-22

Hill, Jr., Robert J.

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Bacteria or actinomycetales; media therefor

435 691, 4353701, 435 6, 536 232, C12N 1512, C12N 1563

Patent

active

053668898

ABSTRACT:
This invention relates to a DNA segment which encodes at least one member of the family of mammalian G protein-coupled receptor kinases, which maps to the Huntington's disease region within the terminal cytogenic subband of the short arm of chromosome 4, 4p16.3, between DNA marker D4S10 and the telomere region. Further, this invention provides the substantially purified expression product of a gene from the Huntington's disease region of the chromosome, as well as related diagnostic and therapeutic uses.

REFERENCES:
patent: 4666828 (1987-05-01), Gusella
P.N.A.S. 90:5588-92 (Jun. 1993) Kunapwli et al. Cloning and expression of GRK5: A member of the G protein-coupled reception Kiwase fault.
Allitto, Bernice A. et al., "Increased Recombination Adjacent to the Huntington Disease-Linked D4S10 Marker", Genomics 9:104-112 (1991).
Altschul, Stephen F. et al., "Basic Local Alignment Search Tool," J. Mol. Biol. 215:403-410 (1990).
Barron, Lilias et al., "Linkage Disequilibrium and Recombination Make a Telomeric Site for the Huntington's Disease Gene Unlikely", J. Med. Genet. 28:520-522 (1991).
Bates, G. P. et al., "Defined Physical Limits of the Huntington Disease Gene Candidate Region", Am. J. Hum. Genet. 49:7-16 (1991).
Benovic, Jeffrey L. et al., ".beta.-Adrenergic Receptor Kinase: Identification of a Novel Protein Kinase That Phosphorylates the Agonist-Occupied Form of the Receptor", PNAS-USA 83:2797-2801 (May 1986).
Benovic, Jeffrey L. et al., "Regulation of Adenylyl Cyclase-Coupled .beta.-Adrenergic Receptors", Ann. Rev. Cell Biol. 4:405-428 (1988).
Benovic, Jeffrey L. et al., "Purification and Characterization of the .beta.-Adrenergic Receptor Kinase", The Journal of Biological Chemistry 262(19):9026-9032 (1987).
Benovic, Jeffrey L. et al., "cDNA Cloning and Chromosomal Localization of the Human .beta.-Adrenergic Receptor Kinase", FEBS 283(1):122-126 (May 1991).
Benovic, Jeffrey L. et al., "Cloning, Expression, and Chromosomal Localization of .beta.-Adrenergic Receptor Kinase 2", The Journal of Biological Chemistry 266(23):14939-14946 (Aug. 15, 1991).
Benovic, Jeffrey L. et al., ".beta.-Adrenergic Receptor Kinase: Primary Structure Delineates a Multigene Family", Science 246:235-240 (Oct. 13, 1989).
Buckler, Alan J. et al, "Exon Amplification: A Strategy to Isolate Mammalian Genes Based on RNA Splicing", PNAS-USA 88:4005-4009 (May 1991).
Cassill, J. Aaron et al., "Isolation of Drosphila Genes Encoding G Protein-Coupled Receptor Kinases", PNAS-USA 88:11067-11070 (Dec. 1991).
Devereux, John et al., "A Comprehensive Set of Sequence Analysis Programs for the VAX", Nucleic Acids Research 12(1):387-395 (1984).
Gilliam, T. Conrad et al., "Localization of the Huntington's Disease Gene to a Small Segment of Chromosome 4 Flanked by D4S10 and the Telomere", Cell 50:565-571 (Aug. 14, 1987).
Gusella, James F. et al., "A Polymorphic DNA Marker Genetically Linked to Huntingtons's Disease", Nature 306:234-238 (1983).
Gusella, James F. et al., "DNA Markers for Nervous System Diseases", Science 225:1320-1326 (Sep. 21, 1984).
Gusella, James F., "Huntington's Disease", Advances In Human Genetics, vol. 20, pp. 125-151 (1991).
Lin, Carol S., "New DNA Markers in the Huntington's Disease Gene Candidate Region", Somatic Cell and Molecular Genetics 17(5):481-488 (1991).
Lorenz, Wulfing et al., "The Receptor Kinase Family: Primary Structure of Rhodopsin Kinase Reveals Similarities to the .beta.-Adrenergic Receptor Kinase", PNAS-USA 88:8715-8719 (Oct. 1991).
MacDonald, Marcy E. et al., "A Somatic Cell Hybrid Panel for Localizing DNA Segments Near the Huntington's Disease Gene", Genomics 1:29-34 (1987).
MacDonald, Marcy E. et al., "The Huntington's Disease Candidate Region Exhibits Many Different Haplotypes", Nature Genetics 1:99-103 (May 1992).
MacDonald, Marcy E. et al., "Recombination Events Suggest Potential Sites for the Huntington's Disase Gene", Neuron 3:183-190 (Aug. 1989).
MacDonald, Marcy E. et al., "Complex Patterns of Linkage Disequalibrium in the Huntington Disease Region", Am. J. Hum. Genet. 49:723-734 (1991).
Marchuk, Douglas et al., "Construction of T-Vectors, A Rapid and General System for Direct Cloning of Unmodified PCR Products", Nucleic Acids Research 19(5):1154 (1991).
Martin, Joseph B. et al., "Huntington's Disease: Pathogenesis and Management", The New England Journal of Medicine 315(20):1267-1276 (Nov. 13, 1986).
Palczewski, Krzysztof et al., "G-Protein-Coupled Receptor Kinases", TIBS 16:387-391 (Oct. 1991).
Sibley, David R. et al., "Regulation of Transmembrane Signaling by Receptor Phosphorylations", Cell 48:913-922 (Mar. 27, 1987).
Smith, Barbara et al., "Isolation of DNA Markers in the Direction of the Huntington Disease Gene from the G8 Locus", Am. J. Hum. Genet. 42:335-344 (1988).
Snell, Russell G., "Linkage Disequilibrium in Huntington's Disease: An Improved Localisation for the Gene", Journal of Medical Genetics 26:673-675 (1989).
Snell, Russell G., "A Recombination Event That Redefines the Huntington Disease Region", Am.J. Hum. Genet. 51:357-362 (1992).
Taylor, S. A. M., "A Dinucleotide Repeat Polymorphism at the D4S127 Locus", Human Molecular Genetics 1(2):142 (1992).
Theilmann, J. et al., "Non-Random Association Between Alleles Detected At D4S95 and D3S98 and the Huntington's Disease Gene", Journal of Medical Genetics 26:676-681 (1989).
Verkerk, Annemieke J. M. H. et al., "Identification of a Gene (FMR-1) Containing a CGG Repeat Coincident with a Breakpoint Cluster Region Exhibiting Length Variation in Fragile X Syndrome", Cell 65:905-914 (May 31, 1991).

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