DNA and mRNA encoding human neuronal nicotinic acetylcholine rec

Chemistry: molecular biology and microbiology – Micro-organism – per se ; compositions thereof; proces of... – Bacteria or actinomycetales; media therefor

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435 691, 435 697, 435 701, 435 711, 435 712, 536 235, 536 253, C12N 120, C12P 2106, C12P 2104, C07H 1700

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053690281

ABSTRACT:
Human neuronal nicotinic acetylcholine receptor subunits are described, as are methods for producing cells containing functional receptors employing such subunits. Also described are assay methods for determining the presence of functional HnAChRs in transfected cells, and for determining the agonist or antagonist activity of compounds with respect to such cells.

REFERENCES:
Marshall et al. The EMBO Journal, vol. 9, No. 13, pp. 4391-4398.
Deneris et al. Neuron, vol. 1, pp. 45-54, 1988.
Kurosaki, et al., "Functional properties of nicotinic acetylcholine recep subunits expressed in various combinations," FEBS Letters 214, 253-258 (1987).
Wada, et al., "Functional expression of a new pharmacological subtype of brain nicotinic acetylcholine receptor," Science, 240:330-334 (1988).
Boulter, et al., "Isolation of a cDNA clone coding for a possible neural nicotinic acetylcholine receptor .alpha.-subunit," Nature, 319:368-374 (1986).
Boulter, et al., "Functional expression of two neuronal nicotinic acetylcholine receptors from cDNA clones identifies a gene family," Proc. Natl. Acad. Sci., 84:7763-7767 (1987).
Goldman, et al., "Members of a nicotinic acetylcholine receptor gene family are expressd in different regions of the mammallian central nervous system," Cell, 48:965-973 (1987).
Patrick, et al., "Acetylcholine receptor metabolism in a nonfusing muscle cell line," J. Biol. Chem., 25:2143-2153 (1977).
Dascal N., "The uses of xenopus oocytes for the study of ion channels," CRC Crit. Rev. Biochem., 22:317-387 (1987).
Clementi, et al., "Pharmacological characterization of cholinergic receptors in a human neuroblastoma cell line," J. Neurochem., 47:291-297 (1986).
Subramani, et al., "Expression of the mouse dihydrofolate reductase complementary deoxyribonucleic acid in simian virus 40," Mol. Cell Biol., 1:854-864 (1981).
Deschamps, et al., "Identification of a transcriptional enhancer element upsteam from the proto-oncogene fos," Science, 230:1174-1177 (1985).

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