Divalent hapten derivatives

Organic compounds -- part of the class 532-570 series – Organic compounds – Nitrogen attached directly or indirectly to the purine ring...

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Details

436543, 436815, 436822, 436823, G01N 33351, C07D23972

Patent

active

047601426

ABSTRACT:
Divalent hapten derivatives wherein two hapten moieties are connected by means of a bifunctional spacer wherein the derivative has the formula

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patent: 4036823 (1977-08-01), Soares
patent: 4308026 (1981-12-01), Mochida et al.
Green et al. "Detection of Antibody Monomers, Dimers and Polymers upon Interaction of a Homologous Series of Divalent Haptens with Its Specific Antibody", Biochemical and Biophysical Research Communications, vol. 46, No. 2 (1972) pp. 738-744.
Margo and Alexander, "In Vitro Studies of Histamine Release from Rabbit Leukocytes by Divalent Haptens", J. Immunol. 1974, 112(5), 1557-61.
Valentine and Green, "Electron Microscopy of an Antibody-Hapten Complex", J. Mol. Biol., (1967) 27, 615-617.
Warner and Schumaker, "Detection of Conformational Change in an Antihapten-Antibody System upon Interaction with Divalent Hapten", Biochemistry, vol. 9, No. 3, (1970) 451-458.
Hyslop et al., "The Fixation of Complement and the Activated First Component (Cl) of Complement by Complexes Formed between Antibody and Divalent Hapten", The Journal of Experimental Medicine, vol. 131, No. 4 (1970) 783-802.

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