Diterpenoid compounds, compositions thereof and their use as...

Details Diterpenoid compounds, compositions thereof and their use as... Diterpenoid compounds, compositions thereof and their use as...

2007-05-15

2007-05-15

Balasubramanian, Venkataraman (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

C544S179000, C544S180000, C544S234000, C544S249000, C544S344000, C514S680000, C514S248000, C514S250000, C514S267000

Reexamination Certificate

active

10725629

ABSTRACT:
The present invention relates to Diterpenoid Compounds, compositions comprising an effective amount of a Diterpenoid Compound, and methods useful for treating or preventing cancer or a neoplastic disorder comprising administering an effective amount of a Diterpenoid Compound. The compounds, compositions, and methods of the invention are also useful for inhibiting the growth of a cancer cell or neoplastic cell, or for inducing apoptosis in a cancer or neoplastic cell. The compounds, compositions, and methods of the invention are further useful for treating or preventing a fungal infection. The compounds, compositions, and methods of the invention are also useful for inhibiting the growth of a fungus.

REFERENCES:
Cecil Textbook of Medicine, edited by Bennet, J.C., and Plum F., 20th edition, vol. 1, 1004-1010, 1996.
Slamenova et al., Basic Clin. Pharmacol. Toxicol. 94(6): 282-290,2004.
Turner et al., Current Pharmaceutical Design. 2, 209-224, 1996.
Sugar et al., Diagn. Microbiol. Infect. Dis. 21: 129-133, 1995.
Cambie et al., 1998, “A Synthesis of Triptoquinones D, E, and F from Podocarpic Acid ,” Aust. J. Chem. 51(10):931-940.
Cambie et al., 1971, Aust. J. Chem. 24:2611.
Carreiras, 1990, “Rearranged abietane diterpenoids from the root ofTeucrium poliumsubsp.vincentinum,” Tetrahedron 46(3):847.
Ceruti et al., 1998, “29-Methylidene-2,3-oxidosqualene derivatives as stereospecific mechanism-based inhibitors of liver and yeast oxidoqualene cyclase,” J. Med. Chem. 41(4):540-554.
Corey et al., 1997, “A Simple Enantioselective Synthesis of the Biologically Active Tetracyclic Marine Sesterterpene Scalarenedial,” J. Am. Chem. Soc. 119:9927-9928.
Crispino et al., 1993, Synthesis 777-779.
Cuadrado et al., 1992, “Rearranged abietane diterpenoids from the root of twoTeucriumspecies,” Phytochemistry 31(5):1697-1701.
Danishefsky et al., 1979, “Derivatives of 1-methoxy-3-trimethylsilyloxy-1,3-butadiene for Diels-Alder reactions,” J. Am. Chem. Soc. 101:7001-7008.
Fishner et al., 2002, “D-ring modified steroids as potent oestrone sulphatase inhibitors,” Eur. J. Cancer 38(7):S125 Abstract 408.
Fuchino et al., 1998, “Two New Abietanes fromLycopodium deuterodensum,” Aust. J. Chem. 1998, 51(2):175.
Greico et al., 1998, “Synthetic Studies on Quassinoids: Total Synthesis and Biological Evaluation of (+)-Des-D-chaparrinone,” J. Org. Chem. 63:5929-5936.
Ito et al., 1978, “Synthesis of .alpha.,.beta.-unsaturated carbonyl compounds by palladium(II)-catalyzed dehydrosilylation of silyl enol ethers,” J. Org. Chem. 43:1011-1013.
Kuehne, 1961, “A Sterospecific Route to the Dehydroabietic Acid Configuration,” J. Amer. Chem. Soc. 83:1492-1498.
Ley et al., 1994, “Tetrapropylammonium Perruthenate, Pr4N+RuO4-, TPAP : Catalytic Oxidant For Organic Synthesis,” Synthesis 639-666.
Lin et al., 2001, “Chemical Constituents fromDrypetes littoralis,” J. Nat. Prod. 64:707-709.
Maercker, 1965, “The Wittig Reaction,” Organic Reactions 14:270-335.
Maryanoff et al., 1985, “Stereochemistry of the Wittig reaction. Effect of nucleophilic groups in the phosphonium ylide,” J. Am. Chem. Soc. 107:217-226.
Murphy et al., 1960, “Structures Related to Morphine. XIV.12′-Hydroxy-5-methyl-2-phenethyl-6,7-benzomorphan, the 9-Demethyl Analog of NIH 7519 (Phenazocine) from 3,4-Dihydro-7-methoxy-2(1H)naphthalenone,” J. Org. Chem. 25:1386-1388.
Nicolaou et al., 2001, Agnew Chem. Int. Ed. 40:207.
Nicolaou et al., 2001, “Selective Oxidation at Carbon Adjacent to Aromatic Systems with IBX ,” J. Am. Chem. Soc. 123:3183-3185.
Poigny et al., 1998, “Efficient Total Synthesis of (-)-Ilimaquinone,” J. Org. Chem. 63:5890-5894.
Rosales et al., 2002, “Regioselective Palladium-Catalyzed Alkylation of Allylic Halides with Benzylic Grignard Reagents. Two-Step Synthesis of Abietane Terpenes and Tetracyclic Polyprenoid Compounds,” J. Org. Chem. 67:1167-1170.
Shishido et al., 1994, “Synthetic studies on diterpenoid quinones with interleukin-1 inhibitory activity. Total synthesis of (.+−.)- and (+)-triptoquinone A,” J. Org. Chem. 59:406-414.
Snider et al., 1985, “Manganese(III)-based oxidative free-radical cyclization. Synthesis of (.+−.)-podocarpic acid,” J. Org. Chem. 50:3659-3661.
Takahashi et al., 1999, Syn. Lett. 5:6444-6446.
Taylor, 1977, “Thallium in organic synthesis. 47. Regioselective ring expansion of cyclic aralkyl ketones via wittig-derived olefins with thallium(III) nitrate (TTN),” Tetrahedron Lett. 18(21):1827-1830.
Thompson et al., 1976, “Stereochemical control of reductions. 5. Effects of electron density and solvent on group haptophilicity,” J. Org. Chem. 41:2903-2906.
Tius et al., 1992, “A novel approach to the synthesis of morphine alkaloids: the synthesis of (d,l)-thebainone-A,” J. Am. Chem. Soc. 114:5959-5966.
Welch et al., 1979, “A stereoselective total synthesis of (.+−.)-gymnomitrol,” J. Am. Chem. Soc. 101:6768-6769.
Woo et al., 2002, “A-ring analogues of oestrone 3-O-sulphamate as potent steroid sulphatase inhibitors and potential anti-cancer agents,” Eur. J. Cancer 38(7):S125 Abstract 415.

Affiliated with

Also associated with

Rating

Diterpenoid compounds, compositions thereof and their use as... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Diterpenoid compounds, compositions thereof and their use as..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Diterpenoid compounds, compositions thereof and their use as... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3760637