Dispersible tablets of dihydroergotoxine methanesulfonate and of

Details Dispersible tablets of dihydroergotoxine methanesulfonate and of Dispersible tablets of dihydroergotoxine methanesulfonate and of

1989-09-26

1991-09-10

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

424464, 424489, 424493, 424499, 424501, A61K 920, A61K 914, A61K 950

Patent

active

050472470

ABSTRACT:
There are described novel dispersible tablets of dihydroergotoxine or of acid addition salts thereof, containing 0.1 to 4% by weight of dihydroergotoxine or its acid addition salts, 4 to 60% by weight of one or more disintegrating agents, 0.8 to 10% by weight of an organic acid and, optionally, 0.2 to 2% by weight of an antioxidizing agent together with other common adjuvants. The process for the manufacture of dispersible tablets of dihydroergotoxine and of acid addition salts thereof is carried out on the basis of known methods by granulating the ingredients and by compressing the granulate to tablets. Dispersible tablets disintegrate within less than 1 minute when brought in contact with water at room temperature to yield a fine dispersion, which facilitates the oral application. Therefore such tablets are particularly suitable for the aged. Dispersible tablets containing dihydroergotoxine or acid addition salts thereof excell by their improved rate of dissolution and good bioavailability.

REFERENCES:
patent: 4122177 (1978-10-01), Fehr

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