Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Tablets – lozenges – or pills
Patent
1989-06-15
1991-12-03
Page, Thurman
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Tablets, lozenges, or pills
424465, 424467, 424468, 424470, 424456, A61K 920
Patent
active
050699105
ABSTRACT:
There are described novel dispersible cimetidine tablets containing 30 to 90% by weight of one of the polymorphous modifications of cimetidine A, B or C, 5 to 55% by weight of one or more disintegrationg agents, 0.05 to 5.0% by weight of a surfactant, such as sodium lauryl sulphate together with other common adjuvants. The process for the manufacture of dispersible cimetidine tablets is effected on the basis of known methods by granulating the ingredients and by compressing the granulate to tablets. Dispersible tablets disintegrate when brought in contact with water at room temperature within less than 1 minute to yield a fine dispersion, which facilitates the oral application. Therefore such tablets are particularly suitable for certain groups of patients, especially for the aged and children. Dispersible tablets containing cimetidine excell by their improved rate of dissolution and good bioavailability.
REFERENCES:
patent: 4693895 (1987-09-01), Wong et al.
patent: 4764380 (1988-08-01), Urguhart et al.
patent: 4824664 (1989-04-01), Tarral et al.
patent: 4851228 (1989-07-01), Zentner et al.
patent: 4853229 (1989-08-01), Theeuwes
A Lievermann, Pharmaceutical Dosage Forms: Tablets, vol. 1 (1980) 79-141.
The Merck Index, 10th Edition (1983), 7432.
H. P. Fieldler, Lexikon der Holfsstoffe fur Pharmazie, Kosmetik und Angrenzende Gebiete, pp. 1123-1125.
Cvelbar Polona
Kofler Bojan
Kopitar Zdravko
Kovacic Mateja
Lampret Marija
LEK
Page Thurman
Piccone Louis A.
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