Directed switch-mediated DNA recombination

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

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4352523, 435325, 435328, 435355, 4353722, 435463, C12N 121, C12N 510, C12N 520, C12N 1500

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059856157

ABSTRACT:
Switch regions derived from an immunoglobulin (Ig) gene are used to direct recombination between a targeting construct containing a promoter, a switch region (S.sub.1), and 2) a target locus minimally containing a promoter, a switch region (S.sub.2), and a target sequence.

REFERENCES:
patent: 4816567 (1989-03-01), Cabilly et al.
patent: 5202238 (1993-04-01), Fell et al.
Borzillo et al. (1988) Lineage and stage specificity of isotype switching in humans. J. Immunol. 141:3625-3633, Nov. 1988.
Lepse et al. (1994) Extrachromosomal eukaryotic DNA substrates for switch recombination: analysis of isotype and cell specificity, DNA Cell Biol. 13:1151-1161, Dec. 1994.
Leung et al. (1994) Regulation and targeting of recombination in extrachromosomal substrates carrying immunologlobulin switch region sequences. Mol. Cell. Biol. 14:1450-1458, Feb. 1994.
Harriman et al. (1993) Immunoglobulin class switch recombination. Annu. Rev. Immunol. 11:361-384, 1993.
Dariavach, P. et al., "The Mouse IgH 3'-enhancer," Eur. J. Immunol., 21:1449-1504. (1991).
Flanagan, J.G., et al., "Arrangement of human immunoglobulin heavy chain constant region genes implies evolutionary duplication of a segment containing y , .epsilon. and .alpha. genes," Nature, vol. 300, 23/30, pp. 709-713, (Dec. 1982).
Green, L.L., et al., Antigen-specific human monoclonal antibodies from mice engineered with human lg heavy and light chain YACs, Nature Genetics, vol. 7, pp. 13-21, (May 1994).
Gritzmacher, C., "Molecular Aspects of Heavy-chain Class Switching," Critical Reviews in Immunology, vol. 9, Issue 3, pp. 173-200, (1989).
Honjo, T., "Immunoglobulin Genes," Ann. Rev. Immunol., 1:499-528, (1983).
Marcu, K. B., et al., "A Model for the molecular requirements of immunoglobulin heavy chain class switching," Nature, vol. 298, 87-89, (Jul. 1, 1982).
Mills, Frederick, C., et al., "Human lg S y Regions and Their Participation in Sequential Switching to lgE," J. Immunol., 155:3021-3036, (1995).
Mowatt, M. R., et al., "DNA Sequence of the Murine y 1 Switch Segment Reveals Novel Structural Elements," Journal of Immunology, vol. 136, No. 7, 2674-2683, (Apr. 1, 1986).
Nikaido, T., et al., "Nucleotide Sequences of Switch Regions of Immunoglobulin C.sub.y and C.sub.y Genes and Their Comparison," The Journal of Biological Chemistry, vol. 257, 13:7322-7329, (Jul. 10, 1982).
Rabbits, T.H., et al., "The role of gene deletion in the immunoglobulin heavy chain switch," Nature, vol. 283:351-356, (Jan. 24, 1980).
Shimizu, A., et al., "Trans-Splicing as a Possible Molecular Mechanism for the Multiple Isotype Expression of the Immunoglobulin Gene," J. Exp. Med., 173:1385-1393, (Jun. 1991).
Takahashi, N., et al., "Structure of Human Immunoglobulin Gamma Genes: Implications for Evolution of a Gene Family," Cell, 29:671-679, (Jun. 1982).
Leung, H., et al., "Regulation and Targeting of Recombination in Extrachromosomal Substrates Carrying Immunoglobulin Switch Region Sequences," Molecular And Cellular Biology, vol. 14, No. 2, pp. 1450-1458, (Feb. 1994).
Harriman, W., et al., "Immunoglobulin Class Switch Recombination," Annu. Rev. Immunol., 11:361-84, (1993).
Kadowaki, N. et al. "Immunoglobulin heavy chain class switching, .mu. to y , in a human lymphoma cell line FL-318 carrying a t(14;18)(q32;q21) chromosomal translocation," Leukemia, (England) 9 (7) p. 1139-43, (Jul. 1995).
Lepse, C.L., et al., "Extrachromosomal Eukaryotic DNA Substrates for Switch Recombination: Analysis of Isotype and Cell Specificity," DNA Cell Biol., (US), 13 (12), p.1151-61, (Dec. 1994).
Borzillo, G. V., et al., "Lineage and Stage Specificity of Isotype Switching in Humans," J. Immunol., (US), 141 (10) p. 3625-3633, (Nov. 15, 1988).
Waters, S.H., et al., A B-Cell-Specific Nuclear Protein that Binds to DNA Sites 5' to Immunoglobulin S.alpha. Tandem Repeats Is Regulated During Differentiation,: Mol. Cell Biol., (US), 9 (12) p. 5594-601, (Dec. 1989).

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