Direct cellular energy delivery system

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Liposomes

Reexamination Certificate

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Reexamination Certificate

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07056529

ABSTRACT:
A vesicle comprises ATP and a phospholipid which is a stable vesicle former. The vesicle has a fusion rate of at least 20 vesicle fusions/second.

REFERENCES:
patent: 5540935 (1996-07-01), Miyazaki et al.
patent: 5674528 (1997-10-01), Ogata et al.
patent: 5863556 (1999-01-01), Ruckert et al.
patent: 6011020 (2000-01-01), Gold et al.
patent: 6086851 (2000-07-01), Boni et al.
patent: 6399091 (2002-06-01), Berthold et al.
patent: 6417326 (2002-07-01), Cullis et al.
patent: 03-236320 (1991-10-01), None
Zang, D.; Daosheng, Z.; Huang, Dingjiu; et al., “The Distribution of Liposome-encapsulated ATP in Experimental ischemic Myocardium,”Chemical Abstracts,vol. 109, No. 11, Abstract No. B5657M, sep. 12, 1988.
Ainscow, E.K., and Brand, M.D. (1999) Top-down control analysis of ATP turnover, glycolysis and oxidative phosphorylation in rat hepatocytes. Eur. J. Biochem. 263:671-685.
Arakawa A, Isshiguro S, Ohki K, Tamai M. (1998) Preparation of liposome-encapsulating adenosine triphosphate.Tohuku J Exp Med184:39-47.
Brand, M.D. (1995). Measurement of mitochondrial proton motive force.InBioeneergetics, a Pratical Approach / Brown, G.C., and Cooper, C.E., eds. Oxford University Press. Oxford, 39-62.
Buck, L.T. and P.W. Hochachka, “Anoxic suppression of Na+-K+-ATPase and constant membrane potential in hepatycytes: support for channel arrest,”Am. J. Physiol.265Regulatory Integrative Comp. Physiol. 34:R1020-1025 (1993).
Chien, S., “Metabolic Management”in Organ Procurement and Preservation for Transplantation, 2nded., Ch. 6, pp. 84-109, Springer, Landes Bioscience, Austin, TX (1997).
Connery, C., G. Hicks, and T. Wang, “Positive Correlation of Functional Recovery and Tissue ATP Levels in the Hypothermically Stored Cardiac Explant,”Surgical Forum, 41:282-284 (1990).
Eckert, D. and P. KIm, “Mechanisms of Viral Membrane Fusion and Its Inhibition,”Annu. Rev. Biochej., 70:777-810 (2001).
Ehringer, W., D. Belcher, S. Wassall, and W. Stillwell, “A comparison of the effects of linolenic (18:3Ω3) and docosahexaenoic (22:6Ω3) acids on phospholipid bilayers,”Chem. Phys. Lipids, 54:79-88 (1990).
Ehringer, W., D. Belcher, S. Wassall, and W. Stillwell, “A comparison of α-linolenic acid (18:3Ω3) and γ-linolenic acid (18:3Ω6) in phosphatidylcholine bilayers,”Chem. Phys. Lipids, 57:87-96 (1991).
Fedel{hacek over (s)}ová, M., A. Ziegelhöffer, E-G. Krause, and A. Wallenberger, “Effect of Exogenous Adenosine Triphosphate on the Metabolic State of the Excised Hypothermic Dog Heart,”Circulation Res., 24:617-627 (1969).
Fraley, R., R. Straubinger, G. Rule, E.L. Springer, and D. Papahadjopoulos, “Liposome-Mediated Delivery of Deoxyribonucleic Acid to Cells: Enhanced Efficiency of Delivery Related to Lipid Composition and Incubation Conditions,”Biochem., 20:6978-6987 (1981).
Fremes, S., J. Zhang, R. Furukawa, D. Mickle, et al., “Adenosine Pretreatment for Prolonged Cardiac Storage,”in J. Thorac. Cardiovas. Surg., 110(2):293-301 (1995).
Garrett, F., S. Goel, J. Yasul, and R. Koch, “Liposomes fuse with sperm cells and induce activation by delivery of impermeant agents,”Biochem. Et Biophys. Acta, 1417:77-88 (1999).
Guo-Xing, X., X. Xing-hui, L. Fang-Yu, Z. DeLiang, et al., “Adenosine Triphosphate Liposomes: Encapsulation and Distribution Studies,”Pharmaceut. Res., 7(5)553-557 (1990).
Hirasawa, H., K. Soeda, Y, Ohtake, S. Oda, et al., “Effects of ATP-MgCl2and ATP-Na2Administration on Renal Function and Cellular Metabolism Following Renal Ischemia,”Circulatory Shock, 16:337-346 (1985).
Hochachka, P.W. and P.L. Lutz, “Mechanism, origin, and evolution of anoxia tolerance in animals,”Comp. Biochem. Phys., Part B, 130:435-459 (2001).
Jahn, R. and T.C. Südhof, “Membrane fusion and exocytosis,”Annu. Rev. Biochem. 68:863-911.
Katori, M. and R. Berne, “Release of Adenosine from Anoxic Hearts. Relationship to Coronary Flow,”Circulation Res., 19:420-425 (1966).
Klein, H., J. Schaper, St. Puschmann, Ch. Nienaber, et al., “Loss of canine myocardial nicotinamide adenine dinucleotides determines the transition from reversible to irreversible ischemic damage of myocardial cells,”Basic Res. Cardiol., 76:612-621 (1981).
Kozubek, A., J. Gubernator, E. Przeworska, and M. Stasiuk, “Liposomal drug delivery, a novel approach: PLARosomes,”Acta Biochim. Pol., 47(3):639-649 (2000).
Kristensen, S., “Mechanisms of cell damage and enzyme release,”Danish Med. Bull., 41(4):423-433 (1994).
McAllister, Jr., H., “Histologic Grading of Cardiac Allograft Rejection: A Quantitative Approach,”J. Heart. Transplant, 9(3):277-282 (1990).
Pagano, R. and J. Weinstein, “Interactions of Liposomes with Mammalian Cells,”Ann. Rev. Biophys. Bioeng., 7:435-468 (1978).
Palombo, J., J. Bowers, M. Clouse, A. McCullough, et al., “Hepatic utilization of exogenous nucleotide precursors for restoration of ATP after cold ischemia in rats,”Amer. J. Clin. Nutr., 57:420-427 (1993).
Pearson, M. and G. Rohrmann, “Transfer, Incorporation, and Substitution of Envelope Fusion Proteins among Members of theBaculoviridae, Orthomyxoviridae, and Metaviridae(Insect Retrovirus) Families,”0J. Virology, 76(11):5301-5304 (2002).
Puisieux, F, E. Fattal, M. Lahiani, J. Auger, P. Jouannet, P. Couvreur, and J. Delattre,“Liposomes, an interesting tool to deliver a bioenergetic substrate (ATP) in vitro and in vivo studies,”J Drug Target2:443-448 (1994).
Reimer, K., R. Jennings, and M. Hill,“Total Ischemia in Dog Hearts, in Vitro,”in“High Energy Phosphate Depletion and Associated Defects in Energy Metabolism, Cell Volume Regulation, and Sarcolemmal Intergrity.”Circ. Res., 49:901-911 (1981).
Schiffelers, R., G. Storm, and I. Bakker-Woudenberg, “Liposome-encapsulated aminoglycosides in pre-clinical and clinical studies,”J. Antimicrob. Chemotherap., 48:333-344 (2001).
Siegel, N., W. Glazier, I. Chaudry, K. Gaudio, et al., “Enhanced recovery from acute renal failure by the postischemic infusion of adenine nucleotides and magnesium chloride in rats,”Kidney Int'l, 17:338-349 (1980).
Stringham, J. Southard, G. Anderson, and F. Belzer, “Mechanisms of ATP Depletion in the Cold-Stored Heart,”Transplantation Proc., 23(5):2437-2438 (1991).
Trigiante, G. and W. Huestis, “Selective virus-mediated intracellular delivery of membrane-impermeant compounds by means of plasma membrane vesicles,”Antiviral Res., 45:211-221 (2000).
Whitman, G., R. Kieval, L. Wetstein, S. Seeholzer, et al., “The Relationship between Global Myocardial Ischemia, Left Ventricular Function, Myocardial, Redox State, and High Energy Phosphate Profile. A Phosphorous-31 Nuclear Magnetic Resonance Study,”Surg. Res., 35:332-339 (1983).
Venkatachalam, M., J. Kriesberg, J. Stein, M. Lifschitz, “Salvage of Ischemic Cells by Impermeant Solute and Adenosinetriphosphate,”Lab. Investig., 49(1):1-3 (1983).

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