Diphosphonate-derivatized macromolecules

Details Diphosphonate-derivatized macromolecules Diphosphonate-derivatized macromolecules

1989-05-11

1991-04-30

Moskowitz, Margaret

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

530391, 530408, 530409, 530410, 530345, 530356, 424 11, 424 9, C07K 1706, A61K 4300, A61K 3944, C07F 938

Patent

active

050119133

ABSTRACT:
Diphosphonate-derivatized macromolecules, such as proteins, suitable for use as technetium-99m-based scanning agents and as anticalcification agents are disclosed. The scanning agents are prepared by combining Tc-99m in a +3, +4 and/or +5 oxidation state with the diphosphonate-derivatized macromoleules. Also disclosed are pharmaceutical compositions containing these diphosphonate-derivatized macromolecules and methods for scintigraphic imaging using these diphosphonate-derivatized macromolecules labeled with Tc-99m.

REFERENCES:
patent: 4337240 (1982-06-01), Saklad
patent: 4421735 (1983-12-01), Haber et al.
patent: 4472509 (1984-09-01), Gansow et al.
patent: 4693884 (1987-09-01), Kleiner et al.
patent: 4707440 (1987-11-01), Stavrianopoulos
patent: 4839467 (1989-06-01), Deutsch
Saha et al., "A Study of Protein-binding of .sup.99m Tc-Methylene Diphosphonate in Plasma", 6 International Journal of Nuclear Medicine and Biology 201 (1979) 6(4):201-6 CA92(15):124160w.

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