Diphenylethane compounds containing a saturated heterocyclic gro

Details Diphenylethane compounds containing a saturated heterocyclic gro Diphenylethane compounds containing a saturated heterocyclic gro

1997-02-10

1998-12-01

Higel, Floyd D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514415, 514427, 514428, 548544, 548556, 548570, 548578, C07C 37055, C07C 3917, A61K 31135, A61K 31205

Patent

active

058439838

ABSTRACT:
Compounds of formula (I): ##STR1## wherein: R.sup.1 represents a saturated heterocyclic group attached to the bond or group represented by A through a ring carbon atom; R.sup.2a, R.sup.2b, R.sup.2c, R.sup.3a, R.sup.3b, R.sup.3c and R.sup.3d are hydrogen or various other groups or atoms; and A represents a single bond or an alkylene group having from 1 to 6 carbon atoms are serotonin 2 receptor antagonists and have the ability to inhibit the activity of squalene synthase. They can not only prevent and inhibit the development and progression of arteriosclerosis but can also inhibit thrombosis in arteriosclerotic lesions and can improve hemodynamics.

REFERENCES:
patent: 3360526 (1967-12-01), Minor
patent: 5252586 (1993-10-01), Cain et al.
patent: 5556864 (1996-09-01), Fujimoto et al.
Kikumoto et al, "Syntheses and Platelet Aggregation Inhibitory and Antithrombotic Properties of Chemistry, vol. 33, No. 6, 1990, pp. 1818-1823.

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